| Literature DB >> 18424044 |
James R Corte1, Tianan Fang, Donald J P Pinto, Wei Han, Zilun Hu, Xiang-Jun Jiang, Yun-Long Li, Jolicia F Gauuan, Mark Hadden, Darren Orton, Alan R Rendina, Joseph M Luettgen, Pancras C Wong, Kan He, Paul E Morin, Chong-Hwan Chang, Daniel L Cheney, Robert M Knabb, Ruth R Wexler, Patrick Y S Lam.
Abstract
Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit arteriovenous-shunt (AV) thrombosis model.Entities:
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Year: 2008 PMID： 18424044 DOI： 10.1016/j.bmcl.2008.03.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823