BACKGROUND: Disorganization is a core dysfunction in schizophrenia. Coherent thought and behavior rely on the interactive neural responses to temporally discrete external events. Previous studies have demonstrated that a single visual stimulus (event) is abnormally affected by another (as in backward masking), but the integration (or 'synthesis') of temporally discrete events remains largely unexplored in schizophrenia. We examined the perceived interaction of two elementary visual events in schizophrenia patients, using a psychophysical approach. METHODS: Two brief, spatially-coincident foveal light pulses (5 ms) were presented with different inter-stimulus intervals (ISIs). At ISIs around 100 ms, a substantial proportion of the light pulse pairs was paradoxically perceived as three flashes, a known phenomenon in normal subjects. The subjects reported the number of flashes perceived ('one', 'two' or 'three'). RESULTS: Schizophrenia patients (n=28) reported fewer 'three flashes' than normal controls (n=26) at the ISIs where 'three flash' reports were greatest in normal subjects (90 to 110 ms). On the other hand, at longer ISIs (130-310 ms) patients reported 'three flashes' in more trials than did normal subjects. The perception of three flashes in patients was correlated with certain aspects of clinical status, including the positive and general subscales of the PANSS. DISCUSSION: The alteration of the 'three-flash' illusion in schizophrenia suggests that the synthesis of discrete visual events is temporally 'dilated' or distorted, which might contribute to disorganized thought and behavior.
BACKGROUND: Disorganization is a core dysfunction in schizophrenia. Coherent thought and behavior rely on the interactive neural responses to temporally discrete external events. Previous studies have demonstrated that a single visual stimulus (event) is abnormally affected by another (as in backward masking), but the integration (or 'synthesis') of temporally discrete events remains largely unexplored in schizophrenia. We examined the perceived interaction of two elementary visual events in schizophreniapatients, using a psychophysical approach. METHODS: Two brief, spatially-coincident foveal light pulses (5 ms) were presented with different inter-stimulus intervals (ISIs). At ISIs around 100 ms, a substantial proportion of the light pulse pairs was paradoxically perceived as three flashes, a known phenomenon in normal subjects. The subjects reported the number of flashes perceived ('one', 'two' or 'three'). RESULTS:Schizophreniapatients (n=28) reported fewer 'three flashes' than normal controls (n=26) at the ISIs where 'three flash' reports were greatest in normal subjects (90 to 110 ms). On the other hand, at longer ISIs (130-310 ms) patients reported 'three flashes' in more trials than did normal subjects. The perception of three flashes in patients was correlated with certain aspects of clinical status, including the positive and general subscales of the PANSS. DISCUSSION: The alteration of the 'three-flash' illusion in schizophrenia suggests that the synthesis of discrete visual events is temporally 'dilated' or distorted, which might contribute to disorganized thought and behavior.
Authors: Pamela D Butler; Lara A DeSanti; Jill Maddox; Jill M Harkavy-Friedman; Xavier F Amador; Raymond R Goetz; Daniel C Javitt; Jack M Gorman Journal: Schizophr Res Date: 2003-02-01 Impact factor: 4.939
Authors: Paul G Nestor; Marek Kubicki; Kevin M Spencer; Margaret Niznikiewicz; Robert W McCarley; Martha E Shenton Journal: Schizophr Res Date: 2006-12-05 Impact factor: 4.939
Authors: Philip R Corlett; Guillermo Horga; Paul C Fletcher; Ben Alderson-Day; Katharina Schmack; Albert R Powers Journal: Trends Cogn Sci Date: 2018-12-21 Impact factor: 20.229
Authors: Johanna Balz; Yadira Roa Romero; Julian Keil; Martin Krebber; Michael Niedeggen; Jürgen Gallinat; Daniel Senkowski Journal: Front Psychol Date: 2016-12-06