Literature DB >> 18423403

Adiponectin promotes endothelial progenitor cell number and function.

Rei Shibata1, Carsten Skurk, Noriyuki Ouchi, Gennaro Galasso, Kazuhisa Kondo, Taiki Ohashi, Masayuki Shimano, Shinji Kihara, Toyoaki Murohara, Kenneth Walsh.   

Abstract

Obesity-linked diseases are associated with suppressed endothelial progenitor cell (EPC) function. Adiponectin is an adipose-derived protein that is downregulated in obese and diabetic subjects. Here, we investigated the effects of adiponectin on EPCs. EPC levels did not increase in adiponectin deficient (APN-KO) in response to hindlimb ischemia. Adenovirus-mediated delivery of adiponectin increased EPC levels in both WT and APN-KO mice. Incubation of human peripheral blood mononuclear cells with adiponectin led to an increase of the number of EPCs. Adiponectin induced EPC differentiation into network structures and served as a chemoattractant in EPC migration assays. These data suggest that hypoadiponectinemia may contribute to the depression of EPC levels that are observed in patients with obesity-related cardiovascular disorders.

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Year:  2008        PMID： 18423403      PMCID： PMC2435501          DOI： 10.1016/j.febslet.2008.04.006

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

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Journal:  Circ Res       Date:  2001-07-06       Impact factor: 17.367

2.  Circulating endothelial progenitor cells, vascular function, and cardiovascular risk.

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3.  Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis.

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Journal:  Arterioscler Thromb Vasc Biol       Date:  2003-12-29       Impact factor: 8.311

Review 4.  Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration.

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Journal:  Nat Med       Date:  2003-06       Impact factor: 53.440

5.  Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures.

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6.  Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells.

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7.  Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells.

Authors:  Noriyuki Ouchi; Hideki Kobayashi; Shinji Kihara; Masahiro Kumada; Kaori Sato; Tatsuya Inoue; Tohru Funahashi; Kenneth Walsh
Journal:  J Biol Chem       Date:  2003-10-13       Impact factor: 5.157

8.  Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis.

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10.  The peroxisome proliferator-activated receptor-gamma agonist pioglitazone increases number and function of endothelial progenitor cells in patients with coronary artery disease and normal glucose tolerance.

Authors:  Christian Werner; Christel Hermann Kamani; Christoph Gensch; Michael Böhm; Ulrich Laufs
Journal:  Diabetes       Date:  2007-07-10       Impact factor: 9.461
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  27 in total

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2.  Differential characteristics and in vitro angiogenesis of bone marrow- and peripheral blood-derived endothelial progenitor cells: evidence from avian species.

Authors:  Q A Shah; X Tan; S Bi; X Liu; S Hu
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Review 3.  The evolving role of adiponectin as an additive biomarker in HFrEF.

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Journal:  Heart Fail Rev       Date:  2016-11       Impact factor: 4.214

4.  Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes.

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Journal:  Stem Cells       Date:  2015-01       Impact factor: 6.277

5.  Circulating Adipokines and Vascular Function: Cross-Sectional Associations in a Community-Based Cohort.

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6.  Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase.

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Review 7.  The role and therapeutic potential of endothelial progenitor cells in tumor neovascularization.

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8.  Therapeutic angiogenesis by transplantation of induced pluripotent stem cell-derived Flk-1 positive cells.

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Journal:  BMC Cell Biol       Date:  2010-09-22       Impact factor: 4.241

9.  Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo.

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10.  Globular adiponectin as a complete mesoangioblast regulator: role in proliferation, survival, motility, and skeletal muscle differentiation.

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Journal:  Mol Biol Cell       Date:  2010-01-20       Impact factor: 4.138
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