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Literature DB >> 18423233

Examining nitroxyl in biological systems.

Jon M Fukuto¹, Matthew I Jackson, Nina Kaludercic, Nazareno Paolocci.

Abstract

Nitroxyl (HNO) has received significant recent attention due to its remarkable and novel biological activity and pharmacological potential. Unlike most other commonly studied nitrogen oxides, examination of HNO biology is not straightforward because of its unique chemical properties. Thus, the study of HNO in biological system requires researchers to be aware of this chemistry in order to properly design and interpret experiments. This chapter focuses on the experimental issues associated with the study of HNO and attempts to provide guidelines for working with this novel and fascinating nitrogen oxide.

Entities: Chemical

Mesh：

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Year: 2008 PMID： 18423233 DOI： 10.1016/S0076-6879(07)00826-9

Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600

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Cited

17 in total

1. The shy Angeli and his elusive creature: the HNO route to vasodilation.

Authors: Nazareno Paolocci; David A Wink
Journal: Am J Physiol Heart Circ Physiol Date: 2009-03-13 Impact factor: 4.733

Review 2. GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease.

Authors: Alessandro Cannavo; Walter J Koch
Journal: Cell Signal Date: 2017-01-07 Impact factor: 4.315

3. The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.

Authors: Robert Millikin; Christopher L Bianco; Corey White; Simran S Saund; Stephanie Henriquez; Victor Sosa; Takaaki Akaike; Yoshito Kumagai; Shuhei Soeda; John P Toscano; Joseph Lin; Jon M Fukuto
Journal: Free Radic Biol Med Date: 2016-05-27 Impact factor: 7.376

Review 4. Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function.

Authors: Carlo G Tocchetti; Brian A Stanley; Christopher I Murray; Vidhya Sivakumaran; Sonia Donzelli; Daniele Mancardi; Pasquale Pagliaro; Wei Dong Gao; Jennifer van Eyk; David A Kass; David A Wink; Nazareno Paolocci
Journal: Antioxid Redox Signal Date: 2011-03-03 Impact factor: 8.401

Examining nitroxyl in biological systems.

1. The shy Angeli and his elusive creature: the HNO route to vasodilation.

Review 2. GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease.

3. The chemical biology of protein hydropersulfides: Studies of a possible protective function of biological hydropersulfide generation.

Review 4. Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function.

Review 5. Nitroxyl (HNO) for treatment of acute heart failure.

6. Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.

7. Nitroxyl anion--the universal signalling partner of endogenously produced nitric oxide?

8. The effects of nitroxyl (HNO) on H₂O₂ metabolism and possible mechanisms of HNO signaling.

9. Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function.

10. Discriminative EPR detection of NO and HNO by encapsulated nitronyl nitroxides.