| Literature DB >> 18422776 |
Andrew M Evens1, Paul T Schumacker, Irene B Helenowski, Amareshwar T K Singh, Danijela Dokic, Anjeni Keswani, Elizabeth Kordeluk, Adekunle Raji, Jane N Winter, Borko D Jovanovic, Arne Holmgren, Beverly P Nelson, Leo I Gordon.
Abstract
Hypoxia inducible factors (HIFs) activate oncogenic pathways, while thioredoxins (Trx), including Trx1 and Trx reductases-1 and -2 (TrxR1 and TrxR2), promote HIF-alpha stabilization. In immunoblotting studies in lymphoma cell lines we found that Raji and SUDHL4 cells exhibited normoxic HIF-2alpha protein stabilization. Five cell lines showed increased TrxR1 expression, while only Namalwa, HF1 and SUDHL4 had Trx1 and TrxR2 activation. Tissue microarrays in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) identified different HIF expression among histological subgroups (e.g. 44% DLBCL vs. 11% of FL cases with moderate-to-high expression of HIF-1alpha and HIF-2alpha, P = 0.0017). These data demonstrate that HIF and the thioredoxin family are abnormally activated in lymphoma.Entities:
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Year: 2008 PMID： 18422776 PMCID： PMC2894542 DOI： 10.1111/j.1365-2141.2008.07093.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998