| Literature DB >> 18422303 |
Abstract
Notch signaling regulates cell fate during the development of many tissues. A new Drosophila mutant, rumi, is defective in Notch signaling because it cannot add glucose to serine in epidermal growth factor repeats of Notch extracellular domain. This is the first biological role for glucose covalently attached to a cell surface signaling receptor.Entities:
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Year: 2008 PMID： 18422303 DOI： 10.1021/cb800073x
Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100