Literature DB >> 18421286

Engineering protease specificity made simple, but not simpler.

Enrico Di Cera.   

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Year:  2008        PMID： 18421286      PMCID： PMC2657294          DOI： 10.1038/nchembio0508-270

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  10 in total

Review 1.  Protein engineering of subtilisin.

Authors:  P N Bryan
Journal:  Biochim Biophys Acta       Date:  2000-12-29

2.  Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site.

Authors:  L Vandeputte-Rutten; R A Kramer; J Kroon; N Dekker; M R Egmond; P Gros
Journal:  EMBO J       Date:  2001-09-17       Impact factor: 11.598

3.  Converting trypsin to chymotrypsin: the role of surface loops.

Authors:  L Hedstrom; L Szilagyi; W J Rutter
Journal:  Science       Date:  1992-03-06       Impact factor: 47.728

4.  Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.

Authors:  Navin Varadarajan; Jongsik Gam; Mark J Olsen; George Georgiou; Brent L Iverson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-02       Impact factor: 11.205

5.  Highly active and selective endopeptidases with programmed substrate specificities.

Authors:  Navin Varadarajan; Sarah Rodriguez; Bum-Yeol Hwang; George Georgiou; Brent L Iverson
Journal:  Nat Chem Biol       Date:  2008-05       Impact factor: 15.040

6.  Attempts to convert chymotrypsin to trypsin.

Authors:  I Venekei; L Szilágyi; L Gráf; W J Rutter
Journal:  FEBS Lett       Date:  1996-03-25       Impact factor: 4.124

7.  On the size of the active site in proteases. I. Papain.

Authors:  I Schechter; A Berger
Journal:  Biochem Biophys Res Commun       Date:  1967-04-20       Impact factor: 3.575

Review 8.  A genomic view of the complexity of mammalian proteolytic systems.

Authors:  X S Puente; L M Sánchez; A Gutiérrez-Fernández; G Velasco; C López-Otín
Journal:  Biochem Soc Trans       Date:  2005-04       Impact factor: 5.407

9.  Ala226 to Gly and Ser189 to Asp mutations convert rat chymotrypsin B to a trypsin-like protease.

Authors:  Balázs Jelinek; József Antal; István Venekei; László Gráf
Journal:  Protein Eng Des Sel       Date:  2004-01-20       Impact factor: 1.650

Review 10.  Serine peptidases: classification, structure and function.

Authors:  M J Page; E Di Cera
Journal:  Cell Mol Life Sci       Date:  2008-04       Impact factor: 9.261
  10 in total
  7 in total

1.  Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold.

Authors:  Austin D Vogt; Pradipta Chakraborty; Enrico Di Cera
Journal:  J Biol Chem       Date:  2015-07-27       Impact factor: 5.157

2.  Inhibitory properties of the P1 Tyr variant of antithrombin.

Authors:  Likui Yang; Chandrashekhara Manithody; Shabir H Qureshi; Alireza R Rezaie
Journal:  Biochemistry       Date:  2010-03-30       Impact factor: 3.162

3.  Engineering thrombin for selective specificity toward protein C and PAR1.

Authors:  Francesca Marino; Leslie A Pelc; Austin Vogt; Prafull S Gandhi; Enrico Di Cera
Journal:  J Biol Chem       Date:  2010-04-19       Impact factor: 5.157

Review 4.  Serine proteases.

Authors:  Enrico Di Cera
Journal:  IUBMB Life       Date:  2009-05       Impact factor: 3.885

5.  Enhancing the promiscuity of a member of the Caspase protease family by rational design.

Authors:  Christoph Öhlknecht; Drazen Petrov; Petra Engele; Christina Kröß; Bernhard Sprenger; Andreas Fischer; Nico Lingg; Rainer Schneider; Chris Oostenbrink
Journal:  Proteins       Date:  2020-06-11

6.  Cleavage entropy as quantitative measure of protease specificity.

Authors:  Julian E Fuchs; Susanne von Grafenstein; Roland G Huber; Michael A Margreiter; Gudrun M Spitzer; Hannes G Wallnoefer; Klaus R Liedl
Journal:  PLoS Comput Biol       Date:  2013-04-18       Impact factor: 4.475

7.  Quantitative Correlation of Conformational Binding Enthalpy with Substrate Specificity of Serine Proteases.

Authors:  Birgit J Waldner; Julian E Fuchs; Roland G Huber; Susanne von Grafenstein; Michael Schauperl; Christian Kramer; Klaus R Liedl
Journal:  J Phys Chem B       Date:  2016-01-11       Impact factor: 2.991
  7 in total

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