Literature DB >> 18421230

Equine recurrent uveitis--a spontaneous horse model of uveitis.

Cornelia A Deeg1, Stefanie M Hauck, Barbara Amann, Dirk Pompetzki, Frank Altmann, Albert Raith, Thomas Schmalzl, Manfred Stangassinger, Marius Ueffing.   

Abstract

Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis. We already identified and characterized novel autoantigens (malate dehydrogenase, recoverin, CRALBP) by analyzing the autoantibody-binding pattern of horses affected by spontaneous recurrent uveitis (ERU) to the retinal proteome. CRALBP also seems to be relevant to human autoimmune uveitis. Proteomic screening of vitreous and retinal samples from ERU diseased cases in comparison to healthy controls has led to the identification of a series of differentially regulated proteins, which are functionally linked to the immune system and the maintenance of the blood-retinal barrier. 2008 S. Karger AG, Basel.

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Year:  2008        PMID： 18421230     DOI： 10.1159/000119867

Source DB:  PubMed          Journal:  Ophthalmic Res        ISSN： 0030-3747            Impact factor:   2.892


  20 in total

1.  Equine CD4(+) CD25(high) T cells exhibit regulatory activity by close contact and cytokine-dependent mechanisms in vitro.

Authors:  Eman Hamza; Vinzenz Gerber; Falko Steinbach; Eliane Marti
Journal:  Immunology       Date:  2011-11       Impact factor: 7.397

2.  Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry.

Authors:  Stefanie M Hauck; Johannes Dietter; Roxane L Kramer; Florian Hofmaier; Johanna K Zipplies; Barbara Amann; Annette Feuchtinger; Cornelia A Deeg; Marius Ueffing
Journal:  Mol Cell Proteomics       Date:  2010-07-04       Impact factor: 5.911

Review 3.  Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis.

Authors:  Bettina Wollanke; Hartmut Gerhards; Kerstin Ackermann
Journal:  Microorganisms       Date:  2022-02-07

4.  Spontaneous development of autoimmune uveitis Is CCR2 dependent.

Authors:  YuTing Feeling Chen; Delu Zhou; Todd Metzger; Marianne Gallup; Marion Jeanne; Douglas B Gould; Mark S Anderson; Nancy A McNamara
Journal:  Am J Pathol       Date:  2014-04-13       Impact factor: 4.307

5.  Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis.

Authors:  Margarete E Swadzba; Stefanie M Hauck; Hassan Y Naim; Barbara Amann; Cornelia A Deeg
Journal:  PLoS One       Date:  2012-12-07       Impact factor: 3.240

6.  Osteopontin and fibronectin levels are decreased in vitreous of autoimmune uveitis and retinal expression of both proteins indicates ECM re-modeling.

Authors:  Cornelia A Deeg; Christina Eberhardt; Florian Hofmaier; Barbara Amann; Stefanie M Hauck
Journal:  PLoS One       Date:  2011-12-14       Impact factor: 3.240

7.  Unraveling the equine lymphocyte proteome: differential septin 7 expression associates with immune cells in equine recurrent uveitis.

Authors:  Roxane L Degroote; Stefanie M Hauck; Barbara Amann; Sieglinde Hirmer; Marius Ueffing; Cornelia A Deeg
Journal:  PLoS One       Date:  2014-03-10       Impact factor: 3.240

8.  Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis.

Authors:  Cornelia A Deeg; Barbara Amann; Konstantin Lutz; Sieglinde Hirmer; Karina Lutterberg; Elisabeth Kremmer; Stefanie M Hauck
Journal:  J Neuroinflammation       Date:  2016-04-23       Impact factor: 8.322

9.  Profound re-organization of cell surface proteome in equine retinal pigment epithelial cells in response to in vitro culturing.

Authors:  Christoph M Szober; Stefanie M Hauck; Kerstin N Euler; Kristina J H Fröhlich; Claudia Alge-Priglinger; Marius Ueffing; Cornelia A Deeg
Journal:  Int J Mol Sci       Date:  2012-10-31       Impact factor: 5.923

10.  A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses.

Authors:  Maike Kulbrock; Stefanie Lehner; Julia Metzger; Bernhard Ohnesorge; Ottmar Distl
Journal:  PLoS One       Date:  2013-08-14       Impact factor: 3.240
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