BACKGROUND AND PURPOSE: The frequency of DWI negative cerebral ischemia and clinical factors associated with such a circumstance is not well understood. METHODS: We performed MRI including diffusion-weighted imaging (DWI) in patients with stroke and transient ischemic attack (TIA) within 24 hours of symptom onset and again at 30 days. RESULTS: Of 401 patients, 103 (25.6%) had an initial negative DWI study. In the DWI negative group, among the stroke patients, 6/26 (23.1%) had infarcts on follow-up MRI (4 lacunar and 2 posterior circulation syndromes) and 1 had a rMTT deficit. Among the TIA patients, 4/63 (6.3%) showed rMTT deficits and 2/63 (3.2%) had infarcts on follow-up MRI. CONCLUSIONS: Baseline perfusion weighted imaging sequences may detect ischemia in a small proportion of DWI negative cases. Only those with brain stem location or lacunar syndrome were DWI negative initially and yet had a follow-up imaging confirmation of infarct or a final clinical diagnosis of stroke.
BACKGROUND AND PURPOSE: The frequency of DWI negative cerebral ischemia and clinical factors associated with such a circumstance is not well understood. METHODS: We performed MRI including diffusion-weighted imaging (DWI) in patients with stroke and transient ischemic attack (TIA) within 24 hours of symptom onset and again at 30 days. RESULTS: Of 401 patients, 103 (25.6%) had an initial negative DWI study. In the DWI negative group, among the strokepatients, 6/26 (23.1%) had infarcts on follow-up MRI (4 lacunar and 2 posterior circulation syndromes) and 1 had a rMTT deficit. Among the TIApatients, 4/63 (6.3%) showed rMTT deficits and 2/63 (3.2%) had infarcts on follow-up MRI. CONCLUSIONS: Baseline perfusion weighted imaging sequences may detect ischemia in a small proportion of DWI negative cases. Only those with brain stem location or lacunar syndrome were DWI negative initially and yet had a follow-up imaging confirmation of infarct or a final clinical diagnosis of stroke.
Authors: Gil-Sun Hong; Choong Wook Lee; Mi-Hyun Kim; Seung Won Jang; Sae Rom Chung; Ga Young Yoon; Jeong Kon Kim Journal: Eur Radiol Date: 2016-05-10 Impact factor: 5.315
Authors: Robert A Frank; Santanu Chakraborty; Trevor McGrath; Alexander Mungham; James Ross; Dar Dowlatshahi; Michel Shamy; Grant Stotts Journal: Neuroradiol J Date: 2018-05-03
Authors: Branko N Huisa; William P Neil; Ronald Schrader; Marcel Maya; Benedict Pereira; Nhu T Bruce; Patrick D Lyden Journal: J Stroke Cerebrovasc Dis Date: 2012-12-14 Impact factor: 2.136