| Literature DB >> 18420409 |
Jian Jin1, Yonghui Wang, Feng Wang, Dongchuan Shi, Karl F Erhard, Zining Wu, Brian F Guida, Sarah K Lawrence, David J Behm, Jyoti Disa, Kalindi S Vaidya, Christopher Evans, Lynette J McMillan, Ralph A Rivero, Michael J Neeb, Stephen A Douglas.
Abstract
A series of 2-aminomethyl piperidines has been discovered as novel urotensin-II receptor antagonists. The synthesis, initial structure-activity relationships, and optimization of the initial hit that resulted in the identification of potent, cross-species active, and functional urotensin-II receptor antagonists such as 1a and 11a are described.Entities:
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Year: 2008 PMID： 18420409 DOI： 10.1016/j.bmcl.2008.03.078
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823