Literature DB >> 18419538

HIV-1 variation before seroconversion in men who have sex with men: analysis of acute/early HIV infection in the multicenter AIDS cohort study.

Geoffrey S Gottlieb1, Laura Heath, David C Nickle, Kim G Wong, Stephanie E Leach, Benjamin Jacobs, Surafel Gezahegne, Angélique B van 't Wout, Lisa P Jacobson, Joseph B Margolick, James I Mullins.   

Abstract

Understanding the characteristics of human immunodeficiency virus (HIV) necessary for infection in a new host is a critical goal for acquired immunodeficiency syndrome (AIDS) research. We studied the characteristics of HIV-1 envelope genes in 38 men in the Multicenter AIDS Cohort Study cohort before seroconversion. We found a range of diversity (0.2%-5.6% [median, 0.86%]), V1-V2 loop length (58-93 aa), and potential N-linked glycosylation sites (n = 2-9). However, at least 46% of the men had replicating virus that appeared to have been derived from a single viral variant. Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/microL.

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Year:  2008        PMID： 18419538      PMCID： PMC3419593          DOI： 10.1086/529206

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda.

Authors:  R H Gray; M J Wawer; R Brookmeyer; N K Sewankambo; D Serwadda; F Wabwire-Mangen; T Lutalo; X Li; T vanCott; T C Quinn
Journal:  Lancet       Date:  2001-04-14       Impact factor: 79.321

2.  Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission.

Authors:  Cynthia A Derdeyn; Julie M Decker; Frederic Bibollet-Ruche; John L Mokili; Mark Muldoon; Scott A Denham; Marintha L Heil; Francis Kasolo; Rosemary Musonda; Beatrice H Hahn; George M Shaw; Bette T Korber; Susan Allen; Eric Hunter
Journal:  Science       Date:  2004-03-26       Impact factor: 47.728

3.  Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection.

Authors:  Manish Sagar; Erin Kirkegaard; Ludo Lavreys; Julie Overbaugh
Journal:  AIDS Res Hum Retroviruses       Date:  2006-05       Impact factor: 2.205

4.  Virus population homogenization following acute human immunodeficiency virus type 1 infection.

Authors:  Gerald H Learn; David Muthui; Scott J Brodie; Tuofu Zhu; Kurt Diem; James I Mullins; Lawrence Corey
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

5.  Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.

Authors:  E L Delwart; H W Sheppard; B D Walker; J Goudsmit; J I Mullins
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103

6.  Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection.

Authors:  R Shankarappa; J B Margolick; S J Gange; A G Rodrigo; D Upchurch; H Farzadegan; P Gupta; C R Rinaldo; G H Learn; X He; X L Huang; J I Mullins
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

7.  Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes.

Authors:  Manish Sagar; Erin Kirkegaard; E Michelle Long; Connie Celum; Susan Buchbinder; Eric S Daar; Julie Overbaugh
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

8.  Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1.

Authors:  Kimberly Ritola; Christopher D Pilcher; Susan A Fiscus; Noah G Hoffman; Julie A E Nelson; Kathryn M Kitrinos; Charles B Hicks; Joseph J Eron; Ronald Swanstrom
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

9.  Intrapatient diversity and its correlation with viral setpoint in human immunodeficiency virus type 1 CRF02_A/G-IbNG infection.

Authors:  Indu Mani; Peter Gilbert; Jean-Louis Sankalé; Geoffrey Eisen; Souleymane Mboup; Phyllis J Kanki
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

10.  Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression.

Authors:  Manish Sagar; Ludo Lavreys; Jared M Baeten; Barbra A Richardson; Kishorchandra Mandaliya; Bhavna H Chohan; Joan K Kreiss; Julie Overbaugh
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103
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  47 in total

Review 1.  MicroRNAs in opioid pharmacology.

Authors:  Cheol Kyu Hwang; Yadav Wagley; Ping-Yee Law; Li-Na Wei; Horace H Loh
Journal:  J Neuroimmune Pharmacol       Date:  2011-11-09       Impact factor: 4.147

Review 2.  Targeting Trojan Horse leukocytes for HIV prevention.

Authors:  Deborah J Anderson; Joseph A Politch; Adam M Nadolski; Caitlin D Blaskewicz; Jeffrey Pudney; Kenneth H Mayer
Journal:  AIDS       Date:  2010-01-16       Impact factor: 4.177

3.  Characterization of human immunodeficiency virus type 1 populations containing CXCR4-using variants from recently infected individuals.

Authors:  Wei Huang; Jonathan Toma; Eric Stawiski; Signe Fransen; Terri Wrin; Neil Parkin; Jeannette M Whitcomb; Eoin Coakley; Frederick M Hecht; Steven G Deeks; Rajesh T Gandhi; Susan H Eshleman; Christos J Petropoulos
Journal:  AIDS Res Hum Retroviruses       Date:  2009-08       Impact factor: 2.205

4.  Heterosexual transmission of human immunodeficiency virus type 1 subtype C: Macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization.

Authors:  Jesse Isaacman-Beck; Emilia A Hermann; Yanjie Yi; Sarah J Ratcliffe; Joseph Mulenga; Susan Allen; Eric Hunter; Cynthia A Derdeyn; Ronald G Collman
Journal:  J Virol       Date:  2009-06-10       Impact factor: 5.103

5.  Novel HIV vaccine strategies: overview and perspective.

Authors:  Yehuda Z Cohen; Raphael Dolin
Journal:  Ther Adv Vaccines       Date:  2013-09

6.  Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design.

Authors:  Li-Hua Ping; Sarah B Joseph; Jeffrey A Anderson; Melissa-Rose Abrahams; Jesus F Salazar-Gonzalez; Laura P Kincer; Florette K Treurnicht; Leslie Arney; Suany Ojeda; Ming Zhang; Jessica Keys; E Lake Potter; Haitao Chu; Penny Moore; Maria G Salazar; Shilpa Iyer; Cassandra Jabara; Jennifer Kirchherr; Clement Mapanje; Nobubelo Ngandu; Cathal Seoighe; Irving Hoffman; Feng Gao; Yuyang Tang; Celia Labranche; Benhur Lee; Andrew Saville; Marion Vermeulen; Susan Fiscus; Lynn Morris; Salim Abdool Karim; Barton F Haynes; George M Shaw; Bette T Korber; Beatrice H Hahn; Myron S Cohen; David Montefiori; Carolyn Williamson; Ronald Swanstrom
Journal:  J Virol       Date:  2013-04-24       Impact factor: 5.103

7.  High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men.

Authors:  Hui Li; Katharine J Bar; Shuyi Wang; Julie M Decker; Yalu Chen; Chuanxi Sun; Jesus F Salazar-Gonzalez; Maria G Salazar; Gerald H Learn; Charity J Morgan; Joseph E Schumacher; Peter Hraber; Elena E Giorgi; Tanmoy Bhattacharya; Bette T Korber; Alan S Perelson; Joseph J Eron; Myron S Cohen; Charles B Hicks; Barton F Haynes; Martin Markowitz; Brandon F Keele; Beatrice H Hahn; George M Shaw
Journal:  PLoS Pathog       Date:  2010-05-13       Impact factor: 6.823

8.  Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission.

Authors:  Laura Heath; Susan Conway; Laura Jones; Katherine Semrau; Kyle Nakamura; Jan Walter; W Don Decker; Jason Hong; Thomas Chen; Marintha Heil; Moses Sinkala; Chipepo Kankasa; Donald M Thea; Louise Kuhn; James I Mullins; Grace M Aldrovandi
Journal:  PLoS One       Date:  2010-04-20       Impact factor: 3.240

9.  HIV-1 superinfection in the antiretroviral therapy era: are seroconcordant sexual partners at risk?

Authors:  Mary S Campbell; Geoffrey S Gottlieb; Stephen E Hawes; David C Nickle; Kim G Wong; Wenjie Deng; Thomas M Lampinen; Nancy B Kiviat; James I Mullins
Journal:  PLoS One       Date:  2009-05-28       Impact factor: 3.240

10.  Nef gene evolution from a single transmitted strain in acute SIV infection.

Authors:  Benjamin N Bimber; Pauline Chugh; Elena E Giorgi; Baek Kim; Anthony L Almudevar; Stephen Dewhurst; David H O'Connor; Ha Youn Lee
Journal:  Retrovirology       Date:  2009-06-08       Impact factor: 4.602
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