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Literature DB >> 18418258

Conjugated equine estrogen enhances rats' cognitive, anxiety, and social behavior.

Abstract

The ovarian hormone, 17beta-estradiol (E2), has numerous targets in the body and brain, and can influence cognitive, affective, and social behavior. However, functional effects of commonly prescribed E2-based hormone therapies are less known. The effects of conjugated equine estrogen (CEE) on middle-aged female rats for cognitive (object recognition), anxiety (open field, plus maze), and social (social interaction, lordosis) behavior were compared with vehicle. Our hypothesis that CEE would enhance cognitive, anxiety, and social behavior was supported. CEE improved object recognition, increased time spent on the open arms of the plus maze, and time spent interacting with a conspecific, but did not alter open field behavior or lordosis. Thus, CEE can enhance cognitive, antianxiety, and social behavior of middle-aged rats.

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Year: 2008 PMID： 18418258 PMCID： PMC2572821 DOI： 10.1097/WNR.0b013e3282fe209c

Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837

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