BACKGROUND: Oxidative stress plays an important role in vascular pathology and contributes to the pathophysiology of primary intracerebral hemorrhage (PICH). Glutathione peroxidase 1 (GPX1) is a key enzyme of the antioxidant system. Here, we investigated whether a functional C593T polymorphism of GPX1 gene is associated with PICH in a Polish population. METHODS: Genotyping was performed in 192 PICH patients and 197 unrelated controls matched for age and sex. All were of Caucasian origin. The C593T GPX1 polymorphism was investigated using the polymerase chain reaction/restriction fragment length polymorphism method. RESULTS: Multivariable logistic regression analysis revealed a significant association between genotypes containing the T allele and the entire PICH group (OR = 1.53; 95% CI = 1.02-2.29) and lobar PICH (OR = 2.36; 95% CI = 1.31-4.26) but not nonlobar PICH (OR = 1.19; 95% CI = 0.75-1.89). CONCLUSIONS: We found a positive association between the studied GPX1 polymorphism and lobar PICH in a Polish population. (c) 2008 S. Karger AG, Basel.
BACKGROUND: Oxidative stress plays an important role in vascular pathology and contributes to the pathophysiology of primary intracerebral hemorrhage (PICH). Glutathione peroxidase 1 (GPX1) is a key enzyme of the antioxidant system. Here, we investigated whether a functional C593T polymorphism of GPX1 gene is associated with PICH in a Polish population. METHODS: Genotyping was performed in 192 PICH patients and 197 unrelated controls matched for age and sex. All were of Caucasian origin. The C593TGPX1 polymorphism was investigated using the polymerase chain reaction/restriction fragment length polymorphism method. RESULTS: Multivariable logistic regression analysis revealed a significant association between genotypes containing the T allele and the entire PICH group (OR = 1.53; 95% CI = 1.02-2.29) and lobar PICH (OR = 2.36; 95% CI = 1.31-4.26) but not nonlobar PICH (OR = 1.19; 95% CI = 0.75-1.89). CONCLUSIONS: We found a positive association between the studied GPX1 polymorphism and lobar PICH in a Polish population. (c) 2008 S. Karger AG, Basel.
Authors: Daniel Woo; Guido J Falcone; William J Devan; W Mark Brown; Alessandro Biffi; Timothy D Howard; Christopher D Anderson; H Bart Brouwers; Valerie Valant; Thomas W K Battey; Farid Radmanesh; Miriam R Raffeld; Sylvia Baedorf-Kassis; Ranjan Deka; Jessica G Woo; Lisa J Martin; Mary Haverbusch; Charles J Moomaw; Guangyun Sun; Joseph P Broderick; Matthew L Flaherty; Sharyl R Martini; Dawn O Kleindorfer; Brett Kissela; Mary E Comeau; Jeremiasz M Jagiella; Helena Schmidt; Paul Freudenberger; Alexander Pichler; Christian Enzinger; Björn M Hansen; Bo Norrving; Jordi Jimenez-Conde; Eva Giralt-Steinhauer; Roberto Elosua; Elisa Cuadrado-Godia; Carolina Soriano; Jaume Roquer; Peter Kraft; Alison M Ayres; Kristin Schwab; Jacob L McCauley; Joanna Pera; Andrzej Urbanik; Natalia S Rost; Joshua N Goldstein; Anand Viswanathan; Eva-Maria Stögerer; David L Tirschwell; Magdy Selim; Devin L Brown; Scott L Silliman; Bradford B Worrall; James F Meschia; Chelsea S Kidwell; Joan Montaner; Israel Fernandez-Cadenas; Pilar Delgado; Rainer Malik; Martin Dichgans; Steven M Greenberg; Peter M Rothwell; Arne Lindgren; Agnieszka Slowik; Reinhold Schmidt; Carl D Langefeld; Jonathan Rosand Journal: Am J Hum Genet Date: 2014-03-20 Impact factor: 11.025
Authors: Guido J Falcone; Alessandro Biffi; William J Devan; Jeremiasz M Jagiella; Helena Schmidt; Brett Kissela; Björn M Hansen; Jordi Jimenez-Conde; Eva Giralt-Steinhauer; Roberto Elosua; Elisa Cuadrado-Godia; Carolina Soriano; Alison M Ayres; Kristin Schwab; Joanna Pera; Andrzej Urbanik; Natalia S Rost; Joshua N Goldstein; Anand Viswanathan; Alexander Pichler; Christian Enzinger; Bo Norrving; David L Tirschwell; Magdy Selim; Devin L Brown; Scott L Silliman; Bradford B Worrall; James F Meschia; Chelsea S Kidwell; Joan Montaner; Israel Fernandez-Cadenas; Pilar Delgado; Joseph P Broderick; Steven M Greenberg; Jaume Roquer; Arne Lindgren; Agnieszka Slowik; Reinhold Schmidt; Matthew L Flaherty; Dawn O Kleindorfer; Carl D Langefeld; Daniel Woo; Jonathan Rosand Journal: Stroke Date: 2012-08-28 Impact factor: 7.914
Authors: William J Devan; Guido J Falcone; Christopher D Anderson; Jeremiasz M Jagiella; Helena Schmidt; Björn M Hansen; Jordi Jimenez-Conde; Eva Giralt-Steinhauer; Elisa Cuadrado-Godia; Carolina Soriano; Alison M Ayres; Kristin Schwab; Sylvia Baedorf Kassis; Valerie Valant; Joanna Pera; Andrzej Urbanik; Anand Viswanathan; Natalia S Rost; Joshua N Goldstein; Paul Freudenberger; Eva-Maria Stögerer; Bo Norrving; David L Tirschwell; Magdy Selim; Devin L Brown; Scott L Silliman; Bradford B Worrall; James F Meschia; Chelsea S Kidwell; Joan Montaner; Israel Fernandez-Cadenas; Pilar Delgado; Steven M Greenberg; Jaume Roquer; Arne Lindgren; Agnieszka Slowik; Reinhold Schmidt; Daniel Woo; Jonathan Rosand; Alessandro Biffi Journal: Stroke Date: 2013-04-04 Impact factor: 7.914
Authors: Alessandro Biffi; Akshata Sonni; Christopher D Anderson; Brett Kissela; Jeremiasz M Jagiella; Helena Schmidt; Jordi Jimenez-Conde; Björn M Hansen; Israel Fernandez-Cadenas; Lynelle Cortellini; Alison Ayres; Kristin Schwab; Karol Juchniewicz; Andrzej Urbanik; Natalia S Rost; Anand Viswanathan; Thomas Seifert-Held; Eva-Maria Stoegerer; Marta Tomás; Raquel Rabionet; Xavier Estivill; Devin L Brown; Scott L Silliman; Magdy Selim; Bradford B Worrall; James F Meschia; Joan Montaner; Arne Lindgren; Jaume Roquer; Reinhold Schmidt; Steven M Greenberg; Agnieszka Slowik; Joseph P Broderick; Daniel Woo; Jonathan Rosand Journal: Ann Neurol Date: 2010-12 Impact factor: 10.422
Authors: Alessandro Biffi; Christopher D Anderson; Jeremiasz M Jagiella; Helena Schmidt; Brett Kissela; Björn M Hansen; Jordi Jimenez-Conde; Caroline R Pires; Alison M Ayres; Kristin Schwab; Lynelle Cortellini; Joanna Pera; Andrzej Urbanik; Javier M Romero; Natalia S Rost; Joshua N Goldstein; Anand Viswanathan; Alexander Pichler; Christian Enzinger; Raquel Rabionet; Bo Norrving; David L Tirschwell; Magdy Selim; Devin L Brown; Scott L Silliman; Bradford B Worrall; James F Meschia; Chelsea S Kidwell; Joseph P Broderick; Steven M Greenberg; Jaume Roquer; Arne Lindgren; Agnieszka Slowik; Reinhold Schmidt; Daniel Woo; Jonathan Rosand Journal: Lancet Neurol Date: 2011-07-06 Impact factor: 44.182
Authors: Leigh A Johnson; Jack A Phillips; Cortney Mauer; Melissa Edwards; Valerie Hobson Balldin; James R Hall; Robert Barber; Tori L Conger; Eric J Ho; Sid E O'Bryant Journal: BMC Psychiatry Date: 2013-01-04 Impact factor: 3.630