Literature DB >> 18417569

Construction and characterization of a human T-cell lymphotropic virus type 3 infectious molecular clone.

Sébastien Alain Chevalier1, Nga Ling Ko, Sara Calattini, Adeline Mallet, Marie-Christine Prévost, Kylene Kehn, John N Brady, Fatah Kashanchi, Antoine Gessain, Renaud Mahieux.   

Abstract

We and others have uncovered the existence of human T-cell lymphotropic virus type 3 (HTLV-3). We have now generated an HTLV-3 proviral clone. We established that gag, env, pol, pro, and tax/rex as well as minus-strand mRNAs are present in cells transfected with the HTLV-3 clone. HTLV-3 p24(gag) protein is detected in the cell culture supernatant. Transfection of 293T-long terminal repeat (LTR)-green fluorescent protein (GFP) cells with the HTLV-3 clone promotes formation of syncytia, a hallmark of Env expression, together with the appearance of fluorescent cells, demonstrating that Tax is expressed. Viral particles are visible by electron microscopy. These particles are infectious, as demonstrated by infection experiments with purified virions.

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Year:  2008        PMID： 18417569      PMCID： PMC2447071          DOI： 10.1128/JVI.00247-08

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

Review 1.  Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation.

Authors:  Michael D Lairmore; Lee Silverman; Lee Ratner
Journal:  Oncogene       Date:  2005-09-05       Impact factor: 9.867

2.  Human T-cell lymphotropic virus type 3: complete nucleotide sequence and characterization of the human tax3 protein.

Authors:  Sara Calattini; Sébastien Alain Chevalier; Renan Duprez; Philippe Afonso; Alain Froment; Antoine Gessain; Renaud Mahieux
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

3.  Complete nucleotide sequence of the new simian T-lymphotropic virus, STLV-PH969 from a Hamadryas baboon, and unusual features of its long terminal repeat.

Authors:  M Van Brüssel; P Goubau; R Rousseau; J Desmyter; A M Vandamme
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

Review 4.  Human T-lymphotropic virus 1: recent knowledge about an ancient infection.

Authors:  Kristien Verdonck; Elsa González; Sonia Van Dooren; Anne-Mieke Vandamme; Guido Vanham; Eduardo Gotuzzo
Journal:  Lancet Infect Dis       Date:  2007-04       Impact factor: 25.071

Review 5.  Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses.

Authors:  J P Slattery; G Franchini; A Gessain
Journal:  Genome Res       Date:  1999-06       Impact factor: 9.043

6.  Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters.

Authors:  Nathan D Wolfe; Walid Heneine; Jean K Carr; Albert D Garcia; Vedapuri Shanmugam; Ubald Tamoufe; Judith N Torimiro; A Tassy Prosser; Matthew Lebreton; Eitel Mpoudi-Ngole; Francine E McCutchan; Deborah L Birx; Thomas M Folks; Donald S Burke; William M Switzer
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-23       Impact factor: 11.205

7.  Ancient origin and molecular features of the novel human T-lymphotropic virus type 3 revealed by complete genome analysis.

Authors:  William M Switzer; Shoukat H Qari; Nathan D Wolfe; Donald S Burke; Thomas M Folks; Walid Heneine
Journal:  J Virol       Date:  2006-08       Impact factor: 5.103

Review 8.  Structural and epidemiological features of primate lymphotropic retroviruses.

Authors:  G Hunsmann; J Schneider; H Bayer; E Jurkiewicz; N Yamamoto
Journal:  Princess Takamatsu Symp       Date:  1984

9.  A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon (Papio hamadryas).

Authors:  P Goubau; M Van Brussel; A M Vandamme; H F Liu; J Desmyter
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-29       Impact factor: 11.205

10.  Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa.

Authors:  Sara Calattini; Sébastien Alain Chevalier; Renan Duprez; Sylviane Bassot; Alain Froment; Renaud Mahieux; Antoine Gessain
Journal:  Retrovirology       Date:  2005-05-09       Impact factor: 4.602
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  8 in total

1.  Human T-cell lymphotropic virus type 3 (HTLV-3)- and HTLV-4-derived antisense transcripts encode proteins with similar Tax-inhibiting functions but distinct subcellular localization.

Authors:  Émilie Larocque; Marilène Halin; Sébastien Landry; Susan J Marriott; William M Switzer; Benoit Barbeau
Journal:  J Virol       Date:  2011-09-14       Impact factor: 5.103

2.  Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription.

Authors:  Marilène Halin; Estelle Douceron; Isabelle Clerc; Chloé Journo; Nga Ling Ko; Sébastien Landry; Edward L Murphy; Antoine Gessain; Isabelle Lemasson; Jean-Michel Mesnard; Benoît Barbeau; Renaud Mahieux
Journal:  Blood       Date:  2009-07-14       Impact factor: 22.113

3.  One-step, multiplex, real-time PCR assay with molecular beacon probes for simultaneous detection, differentiation, and quantification of human T-cell leukemia virus types 1, 2, and 3.

Authors:  Guillaume Besson; Mirdad Kazanji
Journal:  J Clin Microbiol       Date:  2009-02-11       Impact factor: 5.948

4.  The receptor complex associated with human T-cell lymphotropic virus type 3 (HTLV-3) Env-mediated binding and entry is distinct from, but overlaps with, the receptor complexes of HTLV-1 and HTLV-2.

Authors:  Kathryn S Jones; Ying K Huang; Sébastien A Chevalier; Philippe V Afonso; Cari Petrow-Sadowski; Daniel C Bertolette; Antoine Gessain; Francis W Ruscetti; Renaud Mahieux
Journal:  J Virol       Date:  2009-03-11       Impact factor: 5.103

5.  In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome.

Authors:  Silva Hilburn; Aileen Rowan; Maria-Antonietta Demontis; Aidan MacNamara; Becca Asquith; Charles R M Bangham; Graham P Taylor
Journal:  J Infect Dis       Date:  2011-01-05       Impact factor: 5.226

Review 6.  HTLV-3/STLV-3 and HTLV-4 viruses: discovery, epidemiology, serology and molecular aspects.

Authors:  Renaud Mahieux; Antoine Gessain
Journal:  Viruses       Date:  2011-07-08       Impact factor: 5.048

7.  Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4.

Authors:  William M Switzer; Marco Salemi; Shoukat H Qari; Hongwei Jia; Rebecca R Gray; Aris Katzourakis; Susan J Marriott; Kendle N Pryor; Nathan D Wolfe; Donald S Burke; Thomas M Folks; Walid Heneine
Journal:  Retrovirology       Date:  2009-02-02       Impact factor: 4.602

Review 8.  HTLV-3/4 and simian foamy retroviruses in humans: discovery, epidemiology, cross-species transmission and molecular virology.

Authors:  Antoine Gessain; Réjane Rua; Edouard Betsem; Jocelyn Turpin; Renaud Mahieux
Journal:  Virology       Date:  2013-01-05       Impact factor: 3.616
  8 in total

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