Literature DB >> 18416306

Application of natural product-inspired diversity-oriented synthesis to drug discovery.

Lisa A Marcaurelle1, Charles W Johannes.   

Abstract

Natural products have played a critical role in the identification of numerous medicines. Synthetic organic chemistry and combinatorial chemistry strategies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strategies to access novel compounds inspired by natural products will be reviewed.

Mesh：

Substances：

Year:  2008        PMID： 18416306     DOI： 10.1007/978-3-7643-8595-8_3

Source DB:  PubMed          Journal:  Prog Drug Res        ISSN： 0071-786X


  12 in total

1.  Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.

Authors:  Danny Hung-Chieh Chou; Amedeo Vetere; Amit Choudhary; Stephen S Scully; Monica Schenone; Alicia Tang; Rachel Gomez; Sean M Burns; Morten Lundh; Tamara Vital; Eamon Comer; Patrick W Faloon; Vlado Dančík; Christie Ciarlo; Joshiawa Paulk; Mingji Dai; Clark Reddy; Hanshi Sun; Matthew Young; Nicholas Donato; Jacob Jaffe; Paul A Clemons; Michelle Palmer; Steven A Carr; Stuart L Schreiber; Bridget K Wagner
Journal:  J Am Chem Soc       Date:  2015-06-15       Impact factor: 15.419

2.  Potent and selective inhibition of a single alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit by an RNA aptamer.

Authors:  Jae-Seon Park; Congzhou Wang; Yan Han; Zhen Huang; Li Niu
Journal:  J Biol Chem       Date:  2011-03-14       Impact factor: 5.157

3.  Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.

Authors:  Danny Hung-Chieh Chou; Jeremy R Duvall; Baudouin Gerard; Haibo Liu; Bhaumik A Pandya; Byung-Chul Suh; Erin M Forbeck; Patrick Faloon; Bridget K Wagner; Lisa A Marcaurelle
Journal:  ACS Med Chem Lett       Date:  2011-09-08       Impact factor: 4.345

4.  Potent and selective inhibition of the open-channel conformation of AMPA receptors by an RNA aptamer.

Authors:  Zhen Huang; Yan Han; Congzhou Wang; Li Niu
Journal:  Biochemistry       Date:  2010-07-13       Impact factor: 3.162

5.  An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Authors:  Lisa A Marcaurelle; Eamon Comer; Sivaraman Dandapani; Jeremy R Duvall; Baudouin Gerard; Sarathy Kesavan; Maurice D Lee; Haibo Liu; Jason T Lowe; Jean-Charles Marie; Carol A Mulrooney; Bhaumik A Pandya; Ann Rowley; Troy D Ryba; Byung-Chul Suh; Jingqiang Wei; Damian W Young; Lakshmi B Akella; Nathan T Ross; Yan-Ling Zhang; Daniel M Fass; Surya A Reis; Wen-Ning Zhao; Stephen J Haggarty; Michelle Palmer; Michael A Foley
Journal:  J Am Chem Soc       Date:  2010-11-10       Impact factor: 15.419

6.  Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection.

Authors:  Brian N Tse; Thomas M Snyder; Yinghua Shen; David R Liu
Journal:  J Am Chem Soc       Date:  2008-10-29       Impact factor: 15.419

7.  Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet.

Authors:  Hong-xia Guo; Dai-hua Liu; Ying Ma; Jin-feng Liu; Ying Wang; Zhi-yan Du; Xin Wang; Jing-kang Shen; Hong-li Peng
Journal:  Acta Pharmacol Sin       Date:  2009-11       Impact factor: 6.150

8.  Discovery of a tetrazolyl β-carboline with in vitro and in vivo osteoprotective activity under estrogen-deficient conditions.

Authors:  Anirudha Karvande; Shahnawaz Khan; Irfan Khan; Deepti Singh; Vikram Khedgikar; Priyanka Kushwaha; Naseer Ahmad; Priyanka Kothari; Anupam Dhasmana; Ruchir Kant; Ritu Trivedi; Prem M S Chauhan
Journal:  Medchemcomm       Date:  2018-06-12       Impact factor: 3.597

9.  Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

Authors:  Richard W Heidebrecht; Carol Mulrooney; Christopher P Austin; Robert H Barker; Jennifer A Beaudoin; Ken Chih-Chien Cheng; Eamon Comer; Sivaraman Dandapani; Justin Dick; Jeremy R Duvall; Eric H Ekland; David A Fidock; Mark E Fitzgerald; Michael Foley; Rajarshi Guha; Paul Hinkson; Martin Kramer; Amanda K Lukens; Daniela Masi; Lisa A Marcaurelle; Xin-Zhuan Su; Craig J Thomas; Michel Weïwer; Roger C Wiegand; Dyann Wirth; Menghang Xia; Jing Yuan; Jinghua Zhao; Michelle Palmer; Benito Munoz; Stuart Schreiber
Journal:  ACS Med Chem Lett       Date:  2011-12-22       Impact factor: 4.345

10.  Protective effects of L-arabinose in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats.

Authors:  Lei Hao; Xiaoling Lu; Min Sun; Kai Li; Lingmin Shen; Tao Wu
Journal:  Food Nutr Res       Date:  2015-12-10       Impact factor: 3.894
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.