OBJECTIVE: Colonic transit scintigraphy has several advantages in comparison with radio-opaque marker (ROM) techniques but it is limited to specialized centers. The aim of the study was to validate the ROM technique for measuring colonic transit using delayed-release capsules. MATERIAL AND METHODS: Colonic transit is expressed as the sum of the weighted mean marker residence times in the colon (geometric centers). Delayed-release capsules containing radio-opaque markers (DC-ROMs) or scintigraphic methods were compared simultaneously in 10 healthy volunteers. Reproducibility and responsiveness of DC-ROM measurements were evaluated in 10 healthy volunteers at an interval of 2 weeks and after bisacodyl treatment, respectively. RESULTS: The transit profiles between the scintigraphic and DC-ROM methods were highly correlated (r = 0.994, p < 0.01). The reproducibility and responsiveness of DC-ROM measurements were good. Colonic transit measured by DC-ROM correlated with the stool form scale (r = 0.66, p < 0.01). CONCLUSION: The DC-ROM test is simple, highly reproducible, responsive, and appropriate for clinical trials and clinical practice.
OBJECTIVE: Colonic transit scintigraphy has several advantages in comparison with radio-opaque marker (ROM) techniques but it is limited to specialized centers. The aim of the study was to validate the ROM technique for measuring colonic transit using delayed-release capsules. MATERIAL AND METHODS: Colonic transit is expressed as the sum of the weighted mean marker residence times in the colon (geometric centers). Delayed-release capsules containing radio-opaque markers (DC-ROMs) or scintigraphic methods were compared simultaneously in 10 healthy volunteers. Reproducibility and responsiveness of DC-ROM measurements were evaluated in 10 healthy volunteers at an interval of 2 weeks and after bisacodyl treatment, respectively. RESULTS: The transit profiles between the scintigraphic and DC-ROM methods were highly correlated (r = 0.994, p < 0.01). The reproducibility and responsiveness of DC-ROM measurements were good. Colonic transit measured by DC-ROM correlated with the stool form scale (r = 0.66, p < 0.01). CONCLUSION: The DC-ROM test is simple, highly reproducible, responsive, and appropriate for clinical trials and clinical practice.
Authors: A Deiteren; M Camilleri; A E Bharucha; D Burton; S McKinzie; A S Rao; A R Zinsmeister Journal: Neurogastroenterol Motil Date: 2009-12-18 Impact factor: 3.598
Authors: Linda L D Zhong; Chung Wah Cheng; Yawen Chan; King Hong Chan; Ting Wa Lam; Xiao Rui Chen; Chi Tak Wong; Justin C Y Wu; Zhao Xiang Bian Journal: Trials Date: 2013-11-04 Impact factor: 2.279