PRIMARY OBJECTIVE: To assess cognitive sequelae, depression and anxiety following carbon monoxide (CO) poisoning. RESEARCH DESIGN: Prospective cohort study. METHODS AND PROCEDURES: This study prospectively followed 256 patients, 55 with less severe and 201 with more severe CO-poisoning. The prevalence of cognitive sequelae, depression and anxiety at 6 weeks, 6 months and 12 months was compared in patients with less severe and more severe CO-poisoning. MAIN OUTCOMES AND RESULTS: Of the less severe CO-poisoned patients, 39% had cognitive sequelae, 21% depression and 30% anxiety at 6 weeks. Of the more severe CO-poisoned patients, 35% had cognitive sequelae, 16% depression and 11% anxiety at 6 weeks. There was no difference in the prevalence of cognitive sequelae at any time. The prevalence of depression was higher in patients with less compared with more severe CO-poisoning at 6 months (p = 0.04), but not 6 weeks or 12 months. The prevalence of anxiety was higher in patients with less compared to more severe CO-poisoning at 6 weeks (p = 0.008), but not 6 or 12 months. Anxiety decreased over time in the less severe group (p < 0.01). CONCLUSION: CO-related cognitive sequelae, depression and anxiety are common and may be independent of poisoning severity.
PRIMARY OBJECTIVE: To assess cognitive sequelae, depression and anxiety following carbon monoxide (CO) poisoning. RESEARCH DESIGN: Prospective cohort study. METHODS AND PROCEDURES: This study prospectively followed 256 patients, 55 with less severe and 201 with more severe CO-poisoning. The prevalence of cognitive sequelae, depression and anxiety at 6 weeks, 6 months and 12 months was compared in patients with less severe and more severe CO-poisoning. MAIN OUTCOMES AND RESULTS: Of the less severe CO-poisoned patients, 39% had cognitive sequelae, 21% depression and 30% anxiety at 6 weeks. Of the more severe CO-poisoned patients, 35% had cognitive sequelae, 16% depression and 11% anxiety at 6 weeks. There was no difference in the prevalence of cognitive sequelae at any time. The prevalence of depression was higher in patients with less compared with more severe CO-poisoning at 6 months (p = 0.04), but not 6 weeks or 12 months. The prevalence of anxiety was higher in patients with less compared to more severe CO-poisoning at 6 weeks (p = 0.008), but not 6 or 12 months. Anxiety decreased over time in the less severe group (p < 0.01). CONCLUSION: CO-related cognitive sequelae, depression and anxiety are common and may be independent of poisoning severity.
Authors: Jason J Rose; Ling Wang; Qinzi Xu; Charles F McTiernan; Sruti Shiva; Jesus Tejero; Mark T Gladwin Journal: Am J Respir Crit Care Med Date: 2017-03-01 Impact factor: 21.405
Authors: Jason J Rose; Kaitlin A Bocian; Qinzi Xu; Ling Wang; Anthony W DeMartino; Xiukai Chen; Catherine G Corey; Danielle A Guimarães; Ivan Azarov; Xueyin N Huang; Qin Tong; Lanping Guo; Mehdi Nouraie; Charles F McTiernan; Christopher P O'Donnell; Jesús Tejero; Sruti Shiva; Mark T Gladwin Journal: J Biol Chem Date: 2020-03-23 Impact factor: 5.157