| Literature DB >> 18414436 |
Abstract
Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PP(i)), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.Entities:
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Year: 2008 PMID: 18414436 DOI: 10.1038/ki.2008.104
Source DB: PubMed Journal: Kidney Int ISSN: 0085-2538 Impact factor: 10.612