Literature DB >> 18413260

In vitro signaling by MAPK and NFkappaB pathways inhibited by Yersinia YopJ.

Sohini Mukherjee1, Kim Orth.   

Abstract

A procedure for an in vitro signaling assay is described for the MAPK and NFkappaB pathways. The method uses a membrane-cleared lysate that contains all the soluble components required for activating these signaling cascades. The pathways can be activated by variety of molecules, including kinases, G-proteins, and E3 ligases. We demonstrate that YopJ inhibits downstream of all these activators. The in vitro signaling assay is ideal for initial biochemical studies on activators and inhibitors of the MAPK and NFkappaB pathways.

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Year:  2008        PMID： 18413260      PMCID： PMC3432501          DOI： 10.1016/S0076-6879(07)38024-5

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  12 in total

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  8 in total

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