Literature DB >> 184129

Stimulation of myocardial contractility by a new cyclic nucleotide analog, 8-(benzylthio)-N6-n-butyladenosine cyclic 3',5'-phosphate (SQ 80122).

D B Evans, C S Parham, M T Schenck, R J Laffan.   

Abstract

The cyclic nucleotide analog, 8-(benzylthio)-N6-n-butyladenosine cyclic 3',5'-phosphate (SQ 80122) increases contractile force of excised cat right ventricular papillary muscle and stimulates myocardial contractility in the anesthetized dog. The inotropic action of this compound is independent of catecholamines and stimulation of beta-adrenergic receptors in the heart.

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Year:  1976        PMID： 184129

Source DB:  PubMed          Journal:  J Cyclic Nucleotide Res        ISSN： 0095-1544


  3 in total

Review 1.  New mechanisms for positive inotropic agents: focus on the discovery and development of imazodan.

Authors:  R E Weishaar; D Kobylarz-Singer; B A Klinkefus
Journal:  Cardiovasc Drugs Ther       Date:  1989-03       Impact factor: 3.727

2.  The effects of adenosine- and guanosine 3',5'-phosphoric acid benzyl esters on guinea-pig ventricular myocardium.

Authors:  M Korth; J Engels
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

3.  Inotropic and chronotropic effects of N6-substituted derivatives of cyclic AMP as assessed in guinea-pig isolated right atria and papillary muscle.

Authors:  T Kawada; Y Yoshida; S Imai
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739
  3 in total

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