BACKGROUND AND AIMS: Epidemiologic studies on a potential chemopreventive effect of statin therapy have yielded conflicting results. We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort. METHODS: A nested case-control study was conducted among patients > or =50 years of age and with > or =5 years of CRC-free initial follow-up in the General Practice Research Database (GPRD; 1987-2002). Cases consisted of all patients with incident CRC. Up to 10 controls were matched with each case on practice site and both duration and calendar time of follow-up prior to the index date. The primary exposure of interest was > or =5 years of cumulative statin use. RESULTS: We identified 4432 incident CRC cases and 44 292 controls. The adjusted odds ratio (OR) for > or =5 years of statin exposure was 1.1 (95% confidence interval (CI): 0.5-2.2). Chronic NSAID/aspirin use did not modify this primary association (test for interaction, p = 0.5). Compared to statin non-users, the adjusted OR for 10 years of statin exposure was 1.3 (95% CI: 0.6-2.7), and the adjusted OR associated with the highest quartile of cumulative statin dose was 1.2 (95% CI: 0.9-1.7). There was a non-statistically significant trend towards a possible reduction in CRC risk among users of high daily statin dose. CONCLUSION: Long-term statin therapy at usual doses was not associated with a significantly reduced risk of CRC. A chemopreventive effect at high daily doses cannot be excluded.
BACKGROUND AND AIMS: Epidemiologic studies on a potential chemopreventive effect of statin therapy have yielded conflicting results. We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort. METHODS: A nested case-control study was conducted among patients > or =50 years of age and with > or =5 years of CRC-free initial follow-up in the General Practice Research Database (GPRD; 1987-2002). Cases consisted of all patients with incident CRC. Up to 10 controls were matched with each case on practice site and both duration and calendar time of follow-up prior to the index date. The primary exposure of interest was > or =5 years of cumulative statin use. RESULTS: We identified 4432 incident CRC cases and 44 292 controls. The adjusted odds ratio (OR) for > or =5 years of statin exposure was 1.1 (95% confidence interval (CI): 0.5-2.2). Chronic NSAID/aspirin use did not modify this primary association (test for interaction, p = 0.5). Compared to statin non-users, the adjusted OR for 10 years of statin exposure was 1.3 (95% CI: 0.6-2.7), and the adjusted OR associated with the highest quartile of cumulative statin dose was 1.2 (95% CI: 0.9-1.7). There was a non-statistically significant trend towards a possible reduction in CRC risk among users of high daily statin dose. CONCLUSION: Long-term statin therapy at usual doses was not associated with a significantly reduced risk of CRC. A chemopreventive effect at high daily doses cannot be excluded.
Authors: Paul J Limburg; Michelle R Mahoney; Katie L Allen Ziegler; Stephen J Sontag; Robert E Schoen; Richard Benya; Michael J Lawson; David S Weinberg; Elena Stoffel; Michael Chiorean; Russell Heigh; Joel Levine; Gary Della'Zanna; Luz Rodriguez; Ellen Richmond; Christopher Gostout; Sumithra J Mandrekar; Thomas C Smyrk Journal: Cancer Prev Res (Phila) Date: 2011-01-05
Authors: Ange Wang; Heather A Wakelee; Aaron K Aragaki; Jean Y Tang; Allison W Kurian; JoAnn E Manson; Marcia L Stefanick Journal: Curr Atheroscler Rep Date: 2016-12 Impact factor: 5.113
Authors: Kimmie Ng; Shuji Ogino; Jeffrey A Meyerhardt; Jennifer A Chan; Andrew T Chan; Donna Niedzwiecki; Donna Hollis; Leonard B Saltz; Robert J Mayer; Al B Benson; Paul L Schaefer; Renaud Whittom; Alexander Hantel; Richard M Goldberg; Monica M Bertagnolli; Alan P Venook; Charles S Fuchs Journal: J Natl Cancer Inst Date: 2011-08-17 Impact factor: 13.506
Authors: G Karadeniz Cakmak; O Irkorucu; B H Ucan; A U Emre; B Bahadir; C Demirtas; O Tascilar; K Karakaya; S Acikgoz; G Kertis; H Ankarali; H Pasaoglu; M Comert Journal: J Gastrointest Surg Date: 2009-07-04 Impact factor: 3.452