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Literature DB >> 18412098

Genetics of post-traumatic stress disorder: informing clinical conceptualizations and promoting future research.

Nicole R Nugent¹, Ananda B Amstadter, Karestan C Koenen.

Abstract

The purpose of this article is to provide an overview of genetic research involving post-traumatic stress disorder (PTSD). First, we summarize evidence for genetic influences on PTSD from family investigations. Second, we discuss the distinct contributions to our understanding of the genetics of PTSD permitted by twin studies. Finally, we summarize findings from molecular genetic studies, which have the potential to inform our understanding of underlying biological mechanisms for the development of PTSD. Copyright 2008 Wiley-Liss, Inc.

Entities: Disease

Mesh：

Year: 2008 PMID： 18412098 PMCID： PMC2680188 DOI： 10.1002/ajmg.c.30169

Source DB: PubMed Journal: Am J Med Genet C Semin Med Genet ISSN： 1552-4868 Impact factor: 3.908

45 in total

Genetics of post-traumatic stress disorder: informing clinical conceptualizations and promoting future research.

1. Urinary catecholamine excretion and severity of PTSD symptoms in Vietnam combat veterans.

2. Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: a study and replication.

3. A twin study of genetic and environmental contributions to liability for posttraumatic stress symptoms.

4. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma.

5. Glucocorticoid receptor polymorphisms and post-traumatic stress disorder.

6. Posttraumatic stress disorder across two generations of Cambodian refugees.

7. Do genes influence exposure to trauma? A twin study of combat.

8. Trauma and posttraumatic stress disorder in the community: the 1996 Detroit Area Survey of Trauma.

9. Posttraumatic stress disorder in the National Comorbidity Survey.

10. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders.

1. Impact of predatory threat on fear extinction in Lewis rats.

Review 2. Risk factors for the development of psychopathology following trauma.

Review 3. Posttraumatic stress disorder in maltreated youth: a review of contemporary research and thought.

4. Pilot Study of a Telehealth-Delivered Medication-Augmented Exposure Therapy Protocol for PTSD.

Review 5. Post-traumatic stress disorder: emerging concepts of pharmacotherapy.

6. The relevance of epigenetics to PTSD: implications for the DSM-V.

7. Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder.

Review 8. Gene-environment interaction in posttraumatic stress disorder: an update.

Review 9. How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.

10. Meta-analyses of the 5-HTTLPR polymorphisms and post-traumatic stress disorder.