Immune system and bone remodeling.

The skeleton undergoes continuous cellular remodeling in a manner similar to that of replacement of a wall, brick by brick. Products of immune cells are likely to modulate all of the cellular events involved in bone remodeling. The local factors that modulate bone cell function and bone remodeling-osteotropic cytokines or growth-regulatory factors-are similar to those involved in other body processes such as wound healing, immune function, oncogenesis, angiogenesis, and embryogenesis.