Human autoimmune thyroid disease A mechanistic update.

Autoimmune thyroid disease refers to a group of common, often familial, disorders of thyroid function, which are associated with disturbances in both cellular and humoral immunity. Current research into autoimmune thyroid disease is characterizing specific target antigens and the cellular and molecular events that lead to tissue-specific immune dysfunction. The thyroid gland is an accessible and useful model for the study of human autoimmune disease. This review highlights some of the more active research areas.