BACKGROUND AND PURPOSE: The aim of the study was to define the added value of whole body FDG-PET in screening for distant metastases in patients with head and neck squamous cell carcinoma and risk factors. MATERIALS AND METHODS: In a multi-center prospective study between 1998 and 2003, 145 consecutive HNSCC patients with risk factors for distant metastases underwent chest CT and whole body FDG-PET for screening of distant metastases. The data of 92 evaluable patients who developed distant metastases or who had a follow-up of at least 12 months were analyzed. Besides their performance in clinical practice, the operational characteristics of PET and CT using ROC analyses were investigated. RESULTS: Pretreatment screening identified distant metastases in 19 patients (21%). FDG-PET had a higher sensitivity (53% vs. 37%) and positive predictive value (80% vs. 75%) than CT. The combination of CT and FDG-PET had the highest sensitivity (63%). The ROC analyses of the five point ordinal scales revealed that the "area under the curve" (AUC) of FDG-PET was significantly higher as compared to CT. CONCLUSION: In HNSCC patients with risk factors, pretreatment screening for distant metastases by chest CT is improved by FDG-PET.
BACKGROUND AND PURPOSE: The aim of the study was to define the added value of whole body FDG-PET in screening for distant metastases in patients with head and neck squamous cell carcinoma and risk factors. MATERIALS AND METHODS: In a multi-center prospective study between 1998 and 2003, 145 consecutive HNSCCpatients with risk factors for distant metastases underwent chest CT and whole body FDG-PET for screening of distant metastases. The data of 92 evaluable patients who developed distant metastases or who had a follow-up of at least 12 months were analyzed. Besides their performance in clinical practice, the operational characteristics of PET and CT using ROC analyses were investigated. RESULTS: Pretreatment screening identified distant metastases in 19 patients (21%). FDG-PET had a higher sensitivity (53% vs. 37%) and positive predictive value (80% vs. 75%) than CT. The combination of CT and FDG-PET had the highest sensitivity (63%). The ROC analyses of the five point ordinal scales revealed that the "area under the curve" (AUC) of FDG-PET was significantly higher as compared to CT. CONCLUSION: In HNSCCpatients with risk factors, pretreatment screening for distant metastases by chest CT is improved by FDG-PET.
Authors: Juan P Rodrigo; Luiz P Kowalski; Carl E Silver; Remco de Bree; Alessandra Rinaldo; Ashok R Shaha; Primož Strojan; Mohamed N Elsheikh; Missak Haigentz; Alvaro Sanabria; H Hakan Coskun; Robert P Takes; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2013-11-26 Impact factor: 2.503
Authors: Magis Mandapathil; Marion Roessler; Jochen A Werner; Carl E Silver; Alessandra Rinaldo; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2014-04-23 Impact factor: 2.503
Authors: Jon Cacicedo; Arturo Navarro; Olga Del Hoyo; Alfonso Gomez-Iturriaga; Filippo Alongi; Jose A Medina; Olgun Elicin; Andrea Skanjeti; Francesco Giammarile; Pedro Bilbao; Francisco Casquero; Berardino de Bari; Alan Dal Pra Journal: Br J Radiol Date: 2016-08-02 Impact factor: 3.039
Authors: James D Murphy; Karen M Chisholm; Megan E Daly; Ellen A Wiegner; Daniel Truong; Andrei Iagaru; Peter G Maxim; Billy W Loo; Edward E Graves; Michael J Kaplan; Christina Kong; Quynh-Thu Le Journal: Radiother Oncol Date: 2011-06-12 Impact factor: 6.280
Authors: Klaus Strobel; Stephan K Haerle; Sandro J Stoeckli; Madeleine Schrank; Jan D Soyka; Patrick Veit-Haibach; Thomas F Hany Journal: Eur J Nucl Med Mol Imaging Date: 2009-02-10 Impact factor: 9.236