Literature DB >> 18408906

[Impending Coumarin-necrosis in a patient with heterozygous protein C deficiency type I].

R Schulze1, W Behr, H Wittwer, S Harwix, K Murmann, W V Scheidt, W Ehret, G Schlimok.   

Abstract

Painful pink or magenta colored skin lesions characterized by a clear line of demarcation between the affected area and surrounding tissue appearing under therapy with coumarins may be a sign for evolving coumarin-necrosis. Immediate treatment with a protein C preparation in patients with protein C deficiency can prevent necrosis.

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Year:  2008        PMID： 18408906     DOI： 10.1007/s00108-008-2119-7

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN： 0020-9554            Impact factor:   0.743


  7 in total

Review 1.  [The pathophysiology, clinical picture and treatment of coumarin-induced necrosis].

Authors:  H Wankmüller; D Ellbrück; E Seifried
Journal:  Dtsch Med Wochenschr       Date:  1991-08-30       Impact factor: 0.628

Review 2.  Clinical management of protein C deficiency.

Authors:  S L Pescatore
Journal:  Expert Opin Pharmacother       Date:  2001-03       Impact factor: 3.889

3.  [Recurrent coumarin necrosis in type II protein S deficiency].

Authors:  H J Seyfarth; A Siegemund; L Helling; M Woinke; D Pfeiffer; C Rühlmann
Journal:  Vasa       Date:  2001-02       Impact factor: 1.961

Review 4.  Cutaneous necrosis induced by acenocoumarol.

Authors:  M Valdivielso; I Longo; M Lecona; P Lázaro
Journal:  J Eur Acad Dermatol Venereol       Date:  2004-03       Impact factor: 6.166

5.  The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects.

Authors:  P H Reitsma; S R Poort; C F Allaart; E Briët; R M Bertina
Journal:  Blood       Date:  1991-08-15       Impact factor: 22.113

6.  Heterozygous protein C deficiency and coumarin necrosis of the skin.

Authors:  M Cucuianu; N Hagău; M Cotul; E Cardan; I Giurgea
Journal:  Rom J Intern Med       Date:  1992 Apr-Jun

7.  Treatment of coumarin-induced skin necrosis with a monoclonal antibody purified protein C concentrate.

Authors:  W Schramm; M Spannagl; K A Bauer; R D Rosenberg; B Birkner; Y Linnau; H P Schwarz
Journal:  Arch Dermatol       Date:  1993-06
  7 in total

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