Adrian Reuben1. 1. Liver Service, Division of Gastroenterology and Hepatology, and Liver Transplant Program, Medical University of South Carolina, Charleston, South Carolina, USA. reubena@musc.edu
Abstract
PURPOSE OF REVIEW: To update the reader with advances in epidemiology, genetics, detection, pathogenesis and therapy of alcohol-related liver disease. RECENT FINDINGS: Ill-health due to alcohol abuse is improving in some nations but deteriorating in others. Oxidative and nitrosative stress are key to the pathogenesis of alcoholic liver disease, and there is now greater emphasis than previously on their development and role of cytochrome P450 2E1, on mitochondrial stress and disruption, (including elucidation of mitochondrial protection mechanisms) disturbance of signaling pathways and involvement of extrahepatic mediators like adiponectin. Treatment of alcoholic liver disease has stagnated, but transplantation is still favored and debated for end-stage cirrhosis. SUMMARY: Basic and clinical research into the mechanisms of alcoholic liver disease is making headway, but has yet to produce safe and effective therapies for alcoholic hepatitis and for reversing cirrhosis.
PURPOSE OF REVIEW: To update the reader with advances in epidemiology, genetics, detection, pathogenesis and therapy of alcohol-related liver disease. RECENT FINDINGS: Ill-health due to alcohol abuse is improving in some nations but deteriorating in others. Oxidative and nitrosative stress are key to the pathogenesis of alcoholic liver disease, and there is now greater emphasis than previously on their development and role of cytochrome P450 2E1, on mitochondrial stress and disruption, (including elucidation of mitochondrial protection mechanisms) disturbance of signaling pathways and involvement of extrahepatic mediators like adiponectin. Treatment of alcoholic liver disease has stagnated, but transplantation is still favored and debated for end-stage cirrhosis. SUMMARY: Basic and clinical research into the mechanisms of alcoholic liver disease is making headway, but has yet to produce safe and effective therapies for alcoholic hepatitis and for reversing cirrhosis.
Authors: Scott H Stewart; David G Koch; Douglas M Burgess; Ira R Willner; Adrian Reuben Journal: Alcohol Clin Exp Res Date: 2012-06-22 Impact factor: 3.455
Authors: Justin Knox; Melanie Wall; Katie Witkiewitz; Henry R Kranzler; Daniel Falk; Raye Litten; Karl Mann; Stephanie S O'Malley; Jennifer Scodes; Raymond Anton; Deborah S Hasin Journal: Alcohol Clin Exp Res Date: 2018-10-03 Impact factor: 3.455
Authors: Gergana Deevska; Patrick P Dotson; Mihail Mitov; D Allan Butterfield; Mariana Nikolova-Karakashian Journal: Cells Date: 2021-05-21 Impact factor: 6.600