Jan Storek1. 1. University of Calgary, 3330 Hospital Drive NW, HSC1869, Calgary, T2N 4N1, Canada. jstorek@ucalgary.ca
Abstract
BACKGROUND: After hematopoietic cell transplantation (HCT), there is a prolonged period of immune deficiency. OBJECTIVE: To review the recovery of immunity after HCT, including how it is influenced by the cellular contents of the graft, and therapeutic implications. METHODS: Literature review using Medline. RESULTS/ CONCLUSION: Whereas innate immunity (e.g., epithelial barriers, phagocytes, natural killer cells) typically recovers within weeks post-transplant, the recovery of adaptive immunity takes longer, months for B cells and years for T cells. The recovery is influenced by the graft contents. For example the number of CD34 cells given with the graft affects the tempo of neutrophil recovery, and the number of CD4 T cells given with the graft affects CD4 T cell counts post-transplant. Improved understanding of the relationship between graft contents and immune reconstitution could lead to graft engineering improving transplant outcomes.
BACKGROUND: After hematopoietic cell transplantation (HCT), there is a prolonged period of immune deficiency. OBJECTIVE: To review the recovery of immunity after HCT, including how it is influenced by the cellular contents of the graft, and therapeutic implications. METHODS: Literature review using Medline. RESULTS/ CONCLUSION: Whereas innate immunity (e.g., epithelial barriers, phagocytes, natural killer cells) typically recovers within weeks post-transplant, the recovery of adaptive immunity takes longer, months for B cells and years for T cells. The recovery is influenced by the graft contents. For example the number of CD34 cells given with the graft affects the tempo of neutrophil recovery, and the number of CD4 T cells given with the graft affects CD4 T cell counts post-transplant. Improved understanding of the relationship between graft contents and immune reconstitution could lead to graft engineering improving transplant outcomes.
Authors: Tim Flerlage; Aisha Souquette; E Kaitlynn Allen; Timothy Brahm; Jeremy Chase Crawford; Li Tang; Yilun Sun; Gabriela Maron; Joshua Wolf; Brandon Triplett; Paul G Thomas Journal: Am J Respir Cell Mol Biol Date: 2020-09 Impact factor: 6.914
Authors: Raphael Itzykson; Marie Robin; Helene Moins-Teisserenc; Marc Delord; Marc Busson; Aliénor Xhaard; Flore Sicre de Fontebrune; Régis Peffault de Latour; Antoine Toubert; Gérard Socié Journal: Haematologica Date: 2014-09-26 Impact factor: 9.941
Authors: Ioannis Politikos; Jessica A Lavery; Patrick Hilden; Christina Cho; Taylor Borrill; Molly A Maloy; Sergio A Giralt; Marcel R M van den Brink; Miguel-Angel Perales; Juliet N Barker Journal: Blood Adv Date: 2020-01-14
Authors: Georgine E de Greef; Eric Braakman; Bronno van der Holt; Jeroen J W M Janssen; Eefke Petersen; Vladimir Vucinic; Nicole Thuss; Meriam Grootes; Jan J Cornelissen Journal: Transfusion Date: 2018-12-11 Impact factor: 3.157