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Literature DB >> 18407310

Effective determination method for a cyanobacterial neurotoxin, beta-N-methylamino-L-alanine.

Takuya Kubo¹, Noriko Kato, Ken Hosoya, Kunimitsu Kaya.

Abstract

We developed a simple and effective analysis procedure that includes pretreatment and determination methods for beta-N-methylamino-l-alanine (BMAA), a cyanobacterial neurotoxin. BMAA may be produced by all known groups of cyanobacteria living in freshwater as well as marine environments. In this paper, we report a novel determination method for BMAA. A cation-exchange resin was effective for the selective concentration of BMAA from cyanobacterial extracts and yielded a high recovery rate. Moreover, liquid chromatography (LC)-electrospray ionization mass spectrometry with a hydrophilic LC column was effective for determining BMAA levels. The quantitation limit for BMAA based on selected ion monitoring (SIM) was determined as 0.5 ng at a signal/noise ratio of 5.

Entities: Chemical

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Year: 2008 PMID： 18407310 DOI： 10.1016/j.toxicon.2008.02.015

Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033

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Cited

12 in total

1. Assessment of the non-protein amino acid BMAA in Mediterranean mussel Mytilus galloprovincialis after feeding with estuarine cyanobacteria.

Authors: Mafalda S Baptista; Rita G W Vasconcelos; Paula C Ferreira; C Marisa R Almeida; Vitor M Vasconcelos
Journal: Environ Sci Pollut Res Int Date: 2015-04-24 Impact factor: 4.223

Review 2. A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans.

Authors: N Chernoff; D J Hill; D L Diggs; B D Faison; B M Francis; J R Lang; M M Larue; T-T Le; K A Loftin; J N Lugo; J E Schmid; W M Winnik
Journal: J Toxicol Environ Health B Crit Rev Date: 2017-06-09 Impact factor: 6.393

3. Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure.

Authors: Sara Jonasson; Johan Eriksson; Lotta Berntzon; Zdenek Spácil; Leopold L Ilag; Lars-Olof Ronnevi; Ulla Rasmussen; Birgitta Bergman
Journal: Proc Natl Acad Sci U S A Date: 2010-05-03 Impact factor: 11.205

4. Prominent human health impacts from several marine microbes: history, ecology, and public health implications.

Authors: P K Bienfang; S V Defelice; E A Laws; L E Brand; R R Bidigare; S Christensen; H Trapido-Rosenthal; T K Hemscheidt; D J McGillicuddy; D M Anderson; H M Solo-Gabriele; A B Boehm; L C Backer
Journal: Int J Microbiol Date: 2010-10-11

5. Diatoms: a novel source for the neurotoxin BMAA in aquatic environments.

Authors: Liying Jiang; Johan Eriksson; Sandra Lage; Sara Jonasson; Shiva Shams; Martin Mehine; Leopold L Ilag; Ulla Rasmussen
Journal: PLoS One Date: 2014-01-02 Impact factor: 3.240

6. Beta-N-methylamino-L-alanine: LC-MS/MS optimization, screening of cyanobacterial strains and occurrence in shellfish from Thau, a French Mediterranean lagoon.

Authors: Damien Réveillon; Eric Abadie; Véronique Séchet; Luc Brient; Véronique Savar; Michèle Bardouil; Philipp Hess; Zouher Amzil
Journal: Mar Drugs Date: 2014-11-17 Impact factor: 5.118

10. How the Neurotoxin β-N-Methylamino-l-Alanine Accumulates in Bivalves: Distribution of the Different Accumulation Fractions among Organs.

Authors: Alexandra Lepoutre; Elisabeth J Faassen; A J Zweers; Miquel Lürling; Alain Geffard; Emilie Lance
Journal: Toxins (Basel) Date: 2020-01-21 Impact factor: 4.546