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Literature DB >> 18407157

The 3beta-hydroxysteroid dehydrogenase gene family of enzymes.

Abstract

It now is apparent that a family of closely related genes encode for 3beta- hydroxysteroid dehydrogenase (3betaHSD). Studies on the regulation of these genes are in their infancy, but the regulation appears multifactorial. The various 3betaHSD genes are expressed principally in a tissue-specific manner likely involving separate mechanisms of regulation. To date, two human 3betaHSD genes and their products have been characterized; type I is expressed in placenta, sebaceous glands, and several other nonendocrine tissues, whereas the type II isoform is the principal 3betaHSD of adrenal cortex and gonads.

Entities: Gene Species

Year: 1993 PMID： 18407157 DOI： 10.1016/1043-2760(93)90117-w

Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015

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Cited

11 in total

Review 1. Neurogenic pain and steroid synthesis in the spinal cord.

Authors: Christine Patte-Mensah; Cherkaouia Kibaly; Domitille Boudard; Véronique Schaeffer; Aurélie Béglé; Simona Saredi; Laurence Meyer; Ayikoe G Mensah-Nyagan
Journal: J Mol Neurosci Date: 2006 Impact factor: 3.444

2. No linkage to the 3 beta-HSD gene cluster in a kindred affected with 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase deficiency and early onset hepatic failure.

Authors: A Russell; H Nazer; A Shams; J Sjövall; R Sutcliffe
Journal: Hum Genet Date: 1995-05 Impact factor: 4.132

Review 3. Progesterone as a neurosteroid: actions within the nervous system.

Authors: E E Baulieu; M Schumacher; H Koenig; I Jung-Testas; Y Akwa
Journal: Cell Mol Neurobiol Date: 1996-04 Impact factor: 5.046

4. Immunohistochemical localisation of 3beta-hydroxysteroid dehydrogenase in Sarcocystis spp.

Authors: Murat Yarim; Kader Yildiz; Nalan Kabakci; Siyami Karahan
Journal: Parasitol Res Date: 2004-07-09 Impact factor: 2.289

Review 5. A novel aspect of the cerebellum: biosynthesis of neurosteroids in the Purkinje cell.

Authors: Kazuyoshi Tsutsui; Hirotaka Sakamoto; Kazuyoshi Ukena
Journal: Cerebellum Date: 2003 Impact factor: 3.847

Review 6. Expression, localization and possible actions of 25-Dx, a membraneassociated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum: a new insight into the biosynthesis, metabolism and multiple actions of progesterone as a neurosteroid.

Authors: Hirotaka Sakamoto; Kazuyoshi Ukena; Mitsuhiro Kawata; Kazuyoshi Tsutsui
Journal: Cerebellum Date: 2008 Impact factor: 3.847

The 3beta-hydroxysteroid dehydrogenase gene family of enzymes.

Review 1. Neurogenic pain and steroid synthesis in the spinal cord.

2. No linkage to the 3 beta-HSD gene cluster in a kindred affected with 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase deficiency and early onset hepatic failure.

Review 3. Progesterone as a neurosteroid: actions within the nervous system.

4. Immunohistochemical localisation of 3beta-hydroxysteroid dehydrogenase in Sarcocystis spp.

Review 5. A novel aspect of the cerebellum: biosynthesis of neurosteroids in the Purkinje cell.

Review 6. Expression, localization and possible actions of 25-Dx, a membraneassociated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum: a new insight into the biosynthesis, metabolism and multiple actions of progesterone as a neurosteroid.

7. Rapid estrogen regulation of DHEA metabolism in the male and female songbird brain.

8. Neurosteroid biosynthesis and function in the brain of domestic birds.

Review 9. Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell.

Review 10. Physiology and Pathophysiology of Steroid Biosynthesis, Transport and Metabolism in the Human Placenta.