Literature DB >> 18407109

Evolving role of Gonadotropin-Releasing Hormone antagonists.

K Gordon1, G D Hodgen.   

Abstract

GnRH antagonists, unlike GnRH agonists, do not act via "downregulation." Instead, GnRH antagonists monopolize the GnRH receptors to such an extent that endogenous GnRH is unable to bind to sufficient numbers of GnRH receptors to provoke release of LH/FSH. This fundamental difference in the mechanism of action of GnRH antagonists versus GnRH agonists is anticipated to result in clinical benefits for certain applications.

Entities:  

Year:  1992        PMID： 18407109     DOI： 10.1016/1043-2760(92)90128-n

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  3 in total

1.  Changes in subcellular distribution of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) after treatment with the LH-RH antagonist cetrorelix.

Authors:  Gabor Halmos; Andrew V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

Review 2.  Functional domains of the gonadotropin-releasing hormone receptor.

Authors:  S C Sealfon; R P Millar
Journal:  Cell Mol Neurobiol       Date:  1995-02       Impact factor: 5.046

3.  Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats.

Authors:  M Kovacs; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-09       Impact factor: 11.205
  3 in total

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