Literature DB >> 18407076

Glycoprotein hormone alpha-subunit in pituitary adenomas.

P Beck-Peccoz1, L Persani, G Faglia.   

Abstract

Elevated serum glycoprotein hormone alpha-subunit (alpha-subunit) levels are seen in about one of six patients bearing pituitary adenomas. This finding has particular clinical significance in patients with nonfunctioning pituitary adenomas. Moreover, the measurement of alpha-subunit along with the calculation of the molar ratio between alpha-subunit and TSH, LH, or FSH is helpful in the diagnosis of glycoprotein hormone-secreting pituitary adenomas. Since serum alpha-subunit levels may vary greatly in several physiologic and pathologic conditions, care has to be taken to differentiate abnormal from normal states of alpha-subunit hypersecretion as well as to exclude causes of alpha-subunit overproduction only casually associated with the presence of pituitary tumors.

Entities:  

Year:  1992        PMID： 18407076     DOI： 10.1016/1043-2760(92)90041-x

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  18 in total

1.  Increased levothyroxine requirements presenting as "inappropriate" TSH secretion syndrome in a patient with nephrotic syndrome.

Authors:  M T Collins; A T Remaley; G Csako; F Pucino; M C Skarulis; J E Balow; N J Sarlis
Journal:  J Endocrinol Invest       Date:  2000-06       Impact factor: 4.256

Review 2.  A 2019 update on TSH-secreting pituitary adenomas.

Authors:  P Beck-Peccoz; C Giavoli; A Lania
Journal:  J Endocrinol Invest       Date:  2019-06-07       Impact factor: 4.256

Review 3.  Medical management of thyrotropin-secreting pituitary adenomas.

Authors:  Paolo Beck-Peccoz; Luca Persani
Journal:  Pituitary       Date:  2002       Impact factor: 4.107

Review 4.  Medical therapy of gonadotropin-producing and nonfunctioning pituitary adenomas.

Authors:  Mansur E Shomali; Laurence Katznelson
Journal:  Pituitary       Date:  2002       Impact factor: 4.107

5.  2013 European thyroid association guidelines for the diagnosis and treatment of thyrotropin-secreting pituitary tumors.

Authors:  P Beck-Peccoz; A Lania; A Beckers; K Chatterjee; J-L Wemeau
Journal:  Eur Thyroid J       Date:  2013-05-07

6.  Comprehensive evaluation of thyrotropinomas: single-center 20-year experience.

Authors:  Alice Azzalin; Christina L Appin; Matthew J Schniederjan; Tina Constantin; James C Ritchie; Emir Veledar; Nelson M Oyesiku; Adriana G Ioachimescu
Journal:  Pituitary       Date:  2016-04       Impact factor: 4.107

7.  Gonadotrophin and free alpha-subunit secretion in patients with acromegaly and clinically non-functioning pituitary tumors: anterior pituitary function and the effect of thyrotrophin-releasing hormone.

Authors:  S S Damjanović; V P Popović; M S Petakov; M M Nikolic-Durović; M Z Doknić; M S Gligorović
Journal:  J Endocrinol Invest       Date:  1996-11       Impact factor: 4.256

8.  Pituitary glycoprotein hormones in chronic renal failure: evidence for an uncontrolled alpha-subunit release.

Authors:  G Medri; C Carella; V Padmanabhan; C M Rossi; G Amato; N G De Santo; I Z Beitins; P Beck-Peccoz
Journal:  J Endocrinol Invest       Date:  1993-03       Impact factor: 4.256

9.  Serum FSH bioactivity and inhibin levels in patients with gonadotropin secreting and nonfunctioning pituitary adenomas.

Authors:  S Borgato; L Persani; R Romoli; D Cortelazzi; A Spada; P Beck-Peccoz
Journal:  J Endocrinol Invest       Date:  1998-06       Impact factor: 4.256

Review 10.  Thyrotropin-secreting pituitary adenomas: epidemiology, diagnosis, and management.

Authors:  Fatemeh G Amlashi; Nicholas A Tritos
Journal:  Endocrine       Date:  2016-01-21       Impact factor: 3.633
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