Literature DB >> 18406816

How obesity causes diabetes in Zucker diabetic fatty rats.

R H Unger1.   

Abstract

The mechanisms of adipogenic diabetes in Zucker diabetic fatty (ZDF) rats, a model of obesity complicated by diabetes, are reviewed. In ZDF rats, a mutation in the leptin receptor, OB-R, is associated with leptin resistance, obesity, and increased fat content of islets. Exaggerated nitric oxide (NO) generation, attributed to high intracellular levels of long-chain fatty acids, impairs beta-cell function and prevents their compensation for obesity-induced diabetes. The resulting diabetic hyperglycemia can be completely prevented by agents that inhibit NO production.

Entities:  

Year:  1997        PMID： 18406816     DOI： 10.1016/s1043-2760(97)00094-5

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  21 in total

1.  Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids.

Authors:  I Briaud; J S Harmon; C L Kelpe; V B Segu; V Poitout
Journal:  Diabetes       Date:  2001-02       Impact factor: 9.461

Review 2.  Vasculotoxic effects of insulin and its role in atherosclerosis: what is the evidence?

Authors:  Shailesh Nandish; Oscar Bailon; Jamison Wyatt; John Smith; Adrienne Stevens; Mike Lujan; Robert Chilton
Journal:  Curr Atheroscler Rep       Date:  2011-04       Impact factor: 5.113

3.  The equivocal metabolic response to endotoxaemia in type 2 diabetic and obese ZDF rats.

Authors:  L Belabed; G Senon; M-C Blanc; A Paillard; L Cynober; S Darquy
Journal:  Diabetologia       Date:  2006-04-19       Impact factor: 10.122

4.  Effects of whey proteins on glucose metabolism in normal Wistar rats and Zucker diabetic fatty (ZDF) rats.

Authors:  Søren Gregersen; Sara Bystrup; Ann Overgaard; Per B Jeppesen; Anne C Sønderstgaard Thorup; Erik Jensen; Kjeld Hermansen
Journal:  Rev Diabet Stud       Date:  2014-02-10

5.  The dual PPARalpha/gamma agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats.

Authors:  Lucy C Pickavance; Christian L Brand; Karsten Wassermann; John P H Wilding
Journal:  Br J Pharmacol       Date:  2005-02       Impact factor: 8.739

6.  OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.

Authors:  M Y Wang; K Koyama; M Shimabukuro; C B Newgard; R H Unger
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-20       Impact factor: 11.205

7.  Cardiac remodeling in a rat model of diet-induced obesity.

Authors:  André Soares Leopoldo; Mário Matheus Sugizaki; Ana Paula Lima-Leopoldo; André Ferreira do Nascimento; Renata de Azevedo Melo Luvizotto; Dijon Henrique Salomé de Campos; Katashi Okoshi; Maeli Dal Pai-Silva; Carlos Roberto Padovani; Antonio Carlos Cicogna
Journal:  Can J Cardiol       Date:  2010-10       Impact factor: 5.223

8.  Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity.

Authors:  Amelia Padilla; Magda Descorbeth; Audra L Almeyda; Kimberly Payne; Marino De Leon
Journal:  Brain Res       Date:  2010-11-23       Impact factor: 3.252

9.  Treatment of Zucker diabetic fatty rats with AVE7688 improves vascular and neural dysfunction.

Authors:  C L Oltman; E P Davidson; L J Coppey; T L Kleinschmidt; M A Yorek
Journal:  Diabetes Obes Metab       Date:  2008-06-16       Impact factor: 6.577

10.  Fatty diabetic lung: altered alveolar structure and surfactant protein expression.

Authors:  David J Foster; Priya Ravikumar; Dennis J Bellotto; Roger H Unger; Connie C W Hsia
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-01-08       Impact factor: 5.464
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