| Literature DB >> 18406613 |
Benjamin Amorelli1, Chunhua Yang, Brian Rempel, Stephen G Withers, Spencer Knapp.
Abstract
Several C-1 homologated GlcNAc- and GalNAc-thiazolines, as well as a related GalNAc-thiazole, have been prepared. The compounds are analogues of GlcNAc-thiazoline, a potent transition-state-mimicking inhibitor of retaining beta-N-acetylglycosaminidases. Kinetic evaluation of these fused pyranose-heterocycles against the bacterial N-acetylhexosaminidase SpHex suggests active site steric restrictions around the substrate anomeric carbon.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18406613 DOI： 10.1016/j.bmcl.2008.03.067
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823