Literature DB >> 18406406

Farnesyl diphosphate synthase localizes to the cytoplasm of Trypanosoma cruzi and T. brucei.

Marcela Ferella1, Zhu-Hong Li, Björn Andersson, Roberto Docampo.   

Abstract

The farnesyl diphosphate synthase (FPPS) has previously been characterized in trypanosomes as an essential enzyme for their survival and as the target for bisphosphonates, drugs that are effective both in vitro and in vivo against these parasites. Enzymes from the isoprenoid pathway have been assigned to different compartments in eukaryotes, including trypanosomatids. We here report that FPPS localizes to the cytoplasm of both Trypanosoma cruzi and T. brucei, and is not present in other organelles such as the mitochondria and glycosomes.

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Year:  2008        PMID： 18406406      PMCID： PMC2409970          DOI： 10.1016/j.exppara.2008.02.013

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  36 in total

1.  Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5.

Authors:  G J Gatto; B V Geisbrecht; S J Gould; J M Berg
Journal:  Nat Struct Biol       Date:  2000-12

2.  Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi.

Authors:  S H Szajnman; B N Bailey; R Docampo; J B Rodriguez
Journal:  Bioorg Med Chem Lett       Date:  2001-03-26       Impact factor: 2.823

3.  Squalene synthase as a chemotherapeutic target in Trypanosoma cruzi and Leishmania mexicana.

Authors:  Julio A Urbina; Juan Luis Concepcion; Salomé Rangel; Gonzalo Visbal; Renee Lira
Journal:  Mol Biochem Parasitol       Date:  2002 Nov-Dec       Impact factor: 1.759

4.  Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs.

Authors:  J A Urbina; B Moreno; S Vierkotter; E Oldfield; G Payares; C Sanoja; B N Bailey; W Yan; D A Scott; S N Moreno; R Docampo
Journal:  J Biol Chem       Date:  1999-11-19       Impact factor: 5.157

5.  Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase.

Authors:  A Montalvetti; B N Bailey; M B Martin; G W Severin; E Oldfield; R Docampo
Journal:  J Biol Chem       Date:  2001-07-02       Impact factor: 5.157

6.  Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

Authors:  M B Martin; J S Grimley; J C Lewis; H T Heath; B N Bailey; H Kendrick; V Yardley; A Caldera; R Lira; J A Urbina; S N Moreno; R Docampo; S L Croft; E Oldfield
Journal:  J Med Chem       Date:  2001-03-15       Impact factor: 7.446

7.  Identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. AA-CoA thiolase, hmg-coa synthase, MPPD, and FPP synthase.

Authors:  L M Olivier; W Kovacs; K Masuda; G A Keller; S K Krisans
Journal:  J Lipid Res       Date:  2000-12       Impact factor: 5.922

8.  A solanesyl-diphosphate synthase localizes in glycosomes of Trypanosoma cruzi.

Authors:  Marcela Ferella; Andrea Montalvetti; Peter Rohloff; Kildare Miranda; Jianmin Fang; Silvia Reina; Makoto Kawamukai; Jacqueline Búa; Daniel Nilsson; Carlos Pravia; Alejandro Katzin; Maria B Cassera; Lena Aslund; Björn Andersson; Roberto Docampo; Esteban J Bontempi
Journal:  J Biol Chem       Date:  2006-10-24       Impact factor: 5.157

9.  Correlating structure and affinity for PEX5:PTS1 complexes.

Authors:  Gregory J Gatto; Ernest L Maynard; Anthony L Guerrerio; Brian V Geisbrecht; Stephen J Gould; Jeremy M Berg
Journal:  Biochemistry       Date:  2003-02-18       Impact factor: 3.162

10.  Activity of bisphosphonates against Trypanosoma brucei rhodesiense.

Authors:  Michael B Martin; John M Sanders; Howard Kendrick; Kate de Luca-Fradley; Jared C Lewis; Joshua S Grimley; Erin M Van Brussel; Jeffrey R Olsen; Gary A Meints; Agnieszka Burzynska; Pawel Kafarski; Simon L Croft; Eric Oldfield
Journal:  J Med Chem       Date:  2002-07-04       Impact factor: 7.446
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  7 in total

1.  A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway.

Authors:  Balázs Szöor; Irene Ruberto; Richard Burchmore; Keith R Matthews
Journal:  Genes Dev       Date:  2010-06-15       Impact factor: 11.361

2.  Farnesyl pyrophosphate synthase is essential for the promastigote and amastigote stages in Leishmania major.

Authors:  Sumit Mukherjee; Somrita Basu; Kai Zhang
Journal:  Mol Biochem Parasitol       Date:  2019-03-26       Impact factor: 1.759

3.  Synthesis and biological evaluation of 1-alkylaminomethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii.

Authors:  Tamila Galaka; Bruno N Falcone; Catherine Li; Sergio H Szajnman; Silvia N J Moreno; Roberto Docampo; Juan B Rodriguez
Journal:  Bioorg Med Chem       Date:  2019-07-04       Impact factor: 3.641

4.  Molecular Cloning and Functional Analysis of DXS and FPS Genes from Zanthoxylum bungeanum Maxim.

Authors:  Lu Tian; Jingwei Shi; Lin Yang; Anzhi Wei
Journal:  Foods       Date:  2022-06-14

5.  Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes.

Authors:  Carmen López-Martín; José María Pérez-Victoria; Luis Carvalho; Santiago Castanys; Francisco Gamarro
Journal:  Antimicrob Agents Chemother       Date:  2008-09-15       Impact factor: 5.191

6.  Single-target high-throughput transcription analyses reveal high levels of alternative splicing present in the FPPS/GGPPS from Plasmodium falciparum.

Authors:  Heloisa B Gabriel; Mauro F de Azevedo; Giuseppe Palmisano; Gerhard Wunderlich; Emília A Kimura; Alejandro M Katzin; João M P Alves
Journal:  Sci Rep       Date:  2015-12-21       Impact factor: 4.379

Review 7.  Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs.

Authors:  Joice Castelo Branco Santos; Jonathas Alves de Melo; Sweta Maheshwari; Wendy Marina Toscano Queiroz de Medeiros; Johny Wysllas de Freitas Oliveira; Cláudia Jassica Moreno; L Mario Amzel; Sandra B Gabelli; Marcelo Sousa Silva
Journal:  Molecules       Date:  2020-06-03       Impact factor: 4.411
  7 in total

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