Literature DB >> 18406243

Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys.

D H Abbott1, D A Dumesic, J R Eisner, R J Colman, J W Kemnitz.   

Abstract

The developmental pathophysiology of polycystic ovary syndrome (PCOS) is unknown. However, prenatally androgenized female rhesus monkeys exhibit ovarian and endocrinological features that mimic those found in women with PCOS. Thus, prenatal androgen excess may provide an etiology for hyperandrogenism and anovulation in adulthood.

Entities:  

Year:  1998        PMID： 18406243     DOI： 10.1016/s1043-2760(98)00019-8

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  63 in total

1.  Prenatal testosterone exposure leads to hypertension that is gonadal hormone-dependent in adult rat male and female offspring.

Authors:  Vijayakumar Chinnathambi; Meena Balakrishnan; Chandrasekhar Yallampalli; Kunju Sathishkumar
Journal:  Biol Reprod       Date:  2012-05-03       Impact factor: 4.285

2.  Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function.

Authors:  Aritro Sen; Stephen R Hammes
Journal:  Mol Endocrinol       Date:  2010-05-25

3.  Brief report: autistic-like traits in childhood predict later age at menarche in girls.

Authors:  Andrew J O Whitehouse; Murray T Maybery; Martha Hickey; Deborah M Sloboda
Journal:  J Autism Dev Disord       Date:  2011-08

4.  Prenatal testosterone and dihydrotestosterone exposure disrupts ovine testicular development.

Authors:  Charles L Bormann; Gary D Smith; Vasantha Padmanabhan; Theresa M Lee
Journal:  Reproduction       Date:  2011-04-14       Impact factor: 3.906

Review 5.  Neuroendocrine consequences of androgen excess in female rodents.

Authors:  Eileen M Foecking; Melissa A McDevitt; Maricedes Acosta-Martínez; Teresa H Horton; Jon E Levine
Journal:  Horm Behav       Date:  2008-01-10       Impact factor: 3.587

6.  Ovarian Androgens Maintain High GnRH Neuron Firing Rate in Adult Prenatally-Androgenized Female Mice.

Authors:  Eden A Dulka; Laura L Burger; Suzanne M Moenter
Journal:  Endocrinology       Date:  2020-01-01       Impact factor: 4.736

7.  Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome.

Authors:  C M Bruns; S T Baum; R J Colman; D A Dumesic; J R Eisner; M D Jensen; L D Whigham; D H Abbott
Journal:  Int J Obes (Lond)       Date:  2007-05-01       Impact factor: 5.095

8.  Endocrine antecedents of polycystic ovary syndrome in fetal and infant prenatally androgenized female rhesus monkeys.

Authors:  David H Abbott; Deborah K Barnett; Jon E Levine; Vasantha Padmanabhan; Daniel A Dumesic; Steve Jacoris; Alice F Tarantal
Journal:  Biol Reprod       Date:  2008-04-02       Impact factor: 4.285

9.  Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females.

Authors:  V Padmanabhan; A Veiga-Lopez; D H Abbott; S E Recabarren; C Herkimer
Journal:  Endocrinology       Date:  2009-12-04       Impact factor: 4.736

Review 10.  Effects of prenatal androgens on rhesus monkeys: a model system to explore the organizational hypothesis in primates.

Authors:  Jan Thornton; Julia L Zehr; Michael D Loose
Journal:  Horm Behav       Date:  2009-05       Impact factor: 3.587
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