New insight into the role of dendritic cells in malaria immune pathogenesis.

The mechanism by which the host develops protective immunity to malaria remains poorly understood. Dendritic cells (DCs) are central to the initiation and regulation of the adaptive immune response. Modulation of DC function might enable Plasmodium to evade the immune system. Millington et al. propose one mechanism by which malaria inhibits DC-T-cell interactions without interfering directly with T-cell receptor engagement. The consequence is a decrease in the co-stimulation required to develop an effective immune response.