Literature DB >> 18406020

Expression of cytokine genes following pre- and post-hatch immunization of chickens with herpesvirus of turkeys.

Mohamed Faizal Abdul-Careem1, D Bruce Hunter, Melissa D Lambourne, Leah R Read, Payvand Parvizi, Shayan Sharif.   

Abstract

Induction of immune response as characterised by expression of cytokine genes in the spleen following immunization of pre- and post-hatch chickens with herpesvirus of turkeys (HVT) vaccine was studied. The pattern of expression of IFN-gamma and IL-10 genes in pre-hatch immunized chickens was different from that observed in post-hatch HVT immunized chickens. This expression pattern of cytokine genes was associated with significantly higher HVT transcripts in pre-hatch immunized chickens than in post-hatch immunized chickens. In conclusion, HVT immunization in chickens, irrespective of the age of immunization, stimulates host response characterised by the expression of cytokine genes, such as IFN-gamma and IL-10 in the spleen. However, the age of immunization appears to influence the temporal pattern of IFN-gamma and IL-10 expression as well as replication of HVT.

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Year:  2008        PMID： 18406020     DOI： 10.1016/j.vaccine.2008.02.069

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  8 in total

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8.  Quantitation of cytokine mRNA by real-time RT-PCR during a vaccination trial in a rabbit model of fascioliasis.

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  8 in total

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