| Literature DB >> 18405847 |
Abstract
Pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation can be used as an 'applied science' tool to provide answers on efficacy and safety of new drugs faster and at a lower cost. PK/PD modelling can be used from the preclinical phase through all clinical phases of drug development. Optimal use of PK/PD modelling and simulation will lead to fewer failed compounds, fewer study failures and smaller numbers of studies needed for registration. For PK/PD modelling to fulfil its potential in drug development, it needs to be embraced across the industry and regulatory agencies, and more education on this topic is required.Entities:
Mesh：
Year: 2008 PMID： 18405847 DOI： 10.1016/j.drudis.2008.01.003
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851