Literature DB >> 18405845

Serotoninergic mechanisms in the treatment of obsessive-compulsive disorder.

Andrew W Goddard1, Anantha Shekhar, Aaron F Whiteman, Christopher J McDougle.   

Abstract

Obsessive-compulsive disorder (OCD) is a disabling psychiatric condition affecting 1-2% of the community. Although modern drug, behavioral and psychosurgical therapies have improved the prognosis of OCD considerably, approximately 30% of patients remain treatment-refractory. Currently, selective serotonin (5-HT) reuptake inhibitors (SSRIs) are the drug treatments of choice for OCD. Accordingly, this review evaluates the evidence for a role of the serotonin (5-HT) neurochemical system in the treatment and pathophysiology of OCD. However, drug treatment approaches that modify function of interrelated neurochemical systems, such as the dopamine and glutamate systems, are also briefly discussed as they promise to complement and enhance SSRI treatment effects.

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Year:  2008        PMID： 18405845     DOI： 10.1016/j.drudis.2007.12.009

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  30 in total

1.  Activation of serotonin 5-HT2A receptors inhibits high compulsive drinking on schedule-induced polydipsia.

Authors:  Silvia Victoria Navarro; Valeria Gutiérrez-Ferre; Pilar Flores; Margarita Moreno
Journal:  Psychopharmacology (Berl)       Date:  2014-08-26       Impact factor: 4.530

2.  Deconstructing 5-HT6 receptor effects on striatal circuit function.

Authors:  D Eskenazi; M Brodsky; J F Neumaier
Journal:  Neuroscience       Date:  2015-04-28       Impact factor: 3.590

3.  Increased expression of 5-HT₆ receptors in dorsolateral striatum decreases habitual lever pressing, but does not affect learning acquisition of simple operant tasks in rats.

Authors:  Daniel Eskenazi; John F Neumaier
Journal:  Eur J Neurosci       Date:  2011-06-30       Impact factor: 3.386

Review 4.  Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics.

Authors:  Suma Jacob; Angeli Landeros-Weisenberger; James F Leckman
Journal:  Autism Res       Date:  2009-12       Impact factor: 5.216

Review 5.  A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: Mapping the way forward.

Authors:  Geoffrey de Brouwer; Arina Fick; Brian H Harvey; De Wet Wolmarans
Journal:  Cogn Affect Behav Neurosci       Date:  2019-02       Impact factor: 3.282

Review 6.  Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges.

Authors:  De Wet Wolmarans; Isabella M Scheepers; Dan J Stein; Brian H Harvey
Journal:  Metab Brain Dis       Date:  2017-12-06       Impact factor: 3.584

7.  Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder.

Authors:  Susanne Walitza; Zoya Marinova; Edna Grünblatt; Stanley E Lazic; Helmut Remschmidt; Timo D Vloet; Jens R Wendland
Journal:  Neurosci Lett       Date:  2014-08-02       Impact factor: 3.046

8.  Differential contributions of dopamine and serotonin to orbitofrontal cortex function in the marmoset.

Authors:  S C Walker; T W Robbins; A C Roberts
Journal:  Cereb Cortex       Date:  2008-08-22       Impact factor: 5.357

9.  Adenoviral vectors for highly selective gene expression in central serotonergic neurons reveal quantal characteristics of serotonin release in the rat brain.

Authors:  Kheira Benzekhroufa; Beihui Liu; Feige Tang; Anja G Teschemacher; Sergey Kasparov
Journal:  BMC Biotechnol       Date:  2009-03-19       Impact factor: 2.563

10.  Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder.

Authors:  Jonathan T Ting; Guoping Feng
Journal:  Curr Chem Genomics       Date:  2008-01-01
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