Literature DB >> 1840536

Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius.

D J Holmes1, D Drocourt, G Tiraby, E Cundliffe.   

Abstract

An aminoglycoside-resistance-encoding gene (kamC) has been isolated from the sporaricin producer, Saccharopolyspora (Sac.) hirsuta, and expressed both in Streptomyces lividans and Escherichia coli. The pattern of resistance conferred by this gene was identical to that given by another gene (kamB) previously isolated from Streptomyces tenebrarius. In accordance with the known action of the kamB product, the Sac, hirsuta determinant also encodes a methyltransferase that modifies 16S rRNA, thereby rendering ribosomes refractory to certain aminoglycosides. The nucleotide sequences of both genes have been determined and comparison of the deduced amino acid sequences reveals a high degree of similarity.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1840536     DOI： 10.1016/0378-1119(91)90532-g

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  15 in total

Review 1.  Compilation and analysis of DNA sequences associated with apparent streptomycete promoters.

Authors:  W R Strohl
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971

Review 2.  Avoidance of suicide in antibiotic-producing microbes.

Authors:  Eric Cundliffe; Arnold L Demain
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-06       Impact factor: 3.346

3.  Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.

Authors:  Jack A Dunkle; Kellie Vinal; Pooja M Desai; Natalia Zelinskaya; Miloje Savic; Dayne M West; Graeme L Conn; Christine M Dunham
Journal:  Proc Natl Acad Sci U S A       Date:  2014-04-09       Impact factor: 11.205

4.  Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides.

Authors:  Jun-ichi Wachino; Keigo Shibayama; Hiroshi Kurokawa; Kouji Kimura; Kunikazu Yamane; Satowa Suzuki; Naohiro Shibata; Yasuyoshi Ike; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2007-09-17       Impact factor: 5.191

5.  The pseudodisaccharides: a novel class of group I intron splicing inhibitors.

Authors:  J Rogers; J Davies
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971

6.  Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria.

Authors:  Rachel Macmaster; Natalia Zelinskaya; Miloje Savic; C Robert Rankin; Graeme L Conn
Journal:  Nucleic Acids Res       Date:  2010-07-17       Impact factor: 16.971

7.  Expansion of the aminoglycoside-resistance 16S rRNA (m(1)A1408) methyltransferase family: expression and functional characterization of four hypothetical enzymes of diverse bacterial origin.

Authors:  Marta A Witek; Graeme L Conn
Journal:  Biochim Biophys Acta       Date:  2014-06-22

8.  Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin.

Authors:  Elizabeth A Felnagle; Michelle R Rondon; Andrew D Berti; Heidi A Crosby; Michael G Thomas
Journal:  Appl Environ Microbiol       Date:  2007-05-11       Impact factor: 4.792

9.  Heterologous Escherichia coli expression, purification and characterization of the GrmA aminoglycoside-resistance methyltransferase.

Authors:  Ivana Moric; Sanja Bajkic; Miloje Savic; Tatjana Ilic Tomic; Graeme L Conn; Branka Vasiljevic
Journal:  Protein J       Date:  2009-10       Impact factor: 2.371

10.  Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics.

Authors:  Miloje Savic; Josip Lovric; Tatjana Ilic Tomic; Branka Vasiljevic; Graeme L Conn
Journal:  Nucleic Acids Res       Date:  2009-07-09       Impact factor: 16.971
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.