Literature DB >> 18404765

Azadipeptide nitriles: highly potent and proteolytically stable inhibitors of papain-like cysteine proteases.

Reik Löser1, Maxim Frizler, Klaus Schilling, Michael Gütschow.   

Abstract

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Year:  2008        PMID： 18404765     DOI： 10.1002/anie.200705858

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  9 in total

Review 1.  Cysteine cathepsins: their role in tumor progression and recent trends in the development of imaging probes.

Authors:  Reik Löser; Jens Pietzsch
Journal:  Front Chem       Date:  2015-06-23       Impact factor: 5.221

2.  3-Cyano-3-aza-β-amino Acid Derivatives as Inhibitors of Human Cysteine Cathepsins.

Authors:  Janina Schmitz; Anna-Madeleine Beckmann; Adela Dudic; Tianwei Li; Robert Sellier; Ulrike Bartz; Michael Gütschow
Journal:  ACS Med Chem Lett       Date:  2014-08-11       Impact factor: 4.345

3.  On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors.

Authors:  Vinicius Bonatto; Pedro Henrique Jatai Batista; Lorenzo Cianni; Daniela De Vita; Daniel G Silva; Rodrigo Cedron; Daiane Y Tezuka; Sérgio de Albuquerque; Carolina Borsoi Moraes; Caio Haddad Franco; Jerônimo Lameira; Andrei Leitão; Carlos A Montanari
Journal:  RSC Med Chem       Date:  2020-09-09

4.  Antimalarial activity of azadipeptide nitriles.

Authors:  Reik Löser; Jiri Gut; Philip J Rosenthal; Maxim Frizler; Michael Gütschow; Katherine T Andrews
Journal:  Bioorg Med Chem Lett       Date:  2009-10-30       Impact factor: 2.823

5.  Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption.

Authors:  Zhong-Yuan Ren; Irma Machuca-Gayet; Chantal Domenget; Rene Buchet; Yuqing Wu; Pierre Jurdic; Saida Mebarek
Journal:  PLoS One       Date:  2015-07-13       Impact factor: 3.240

6.  Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors.

Authors:  Thomas S Corrigan; Leilani M Lotti Diaz; Sarah E Border; Steven C Ratigan; Kayla Q Kasper; Daniel Sojka; Pavla Fajtova; Conor R Caffrey; Guy S Salvesen; Craig A McElroy; Christopher M Hadad; Özlem Doğan Ekici
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

7.  Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity.

Authors:  Adéla Jílková; Martin Horn; Jindřich Fanfrlík; Jim Küppers; Petr Pachl; Pavlína Řezáčová; Martin Lepšík; Pavla Fajtová; Petra Rubešová; Marta Chanová; Conor R Caffrey; Michael Gütschow; Michael Mareš
Journal:  ACS Infect Dis       Date:  2020-12-10       Impact factor: 5.084

8.  Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.

Authors:  Julian Breidenbach; Carina Lemke; Thanigaimalai Pillaiyar; Laura Schäkel; Ghazl Al Hamwi; Miriam Diett; Robin Gedschold; Nina Geiger; Vittoria Lopez; Salahuddin Mirza; Vigneshwaran Namasivayam; Anke C Schiedel; Katharina Sylvester; Dominik Thimm; Christin Vielmuth; Lan Phuong Vu; Maria Zyulina; Jochen Bodem; Michael Gütschow; Christa E Müller
Journal:  Angew Chem Int Ed Engl       Date:  2021-03-24       Impact factor: 16.823

9.  Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes.

Authors:  Jakub Benýšek; Michal Buša; Petra Rubešová; Jindřich Fanfrlík; Martin Lepšík; Jiří Brynda; Zuzana Matoušková; Ulrike Bartz; Martin Horn; Michael Gütschow; Michael Mareš
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051
  9 in total

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