Literature DB >> 18404319

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum.

Toru Yagura1, Tomoko Motomiya, Michiho Ito, Gisho Honda, Akira Iida, Fumiyuki Kiuchi, Harukuni Tokuda, Hoyoku Nishino.   

Abstract

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

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Year:  2008        PMID： 18404319     DOI： 10.1007/s11418-007-0223-y

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


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