Literature DB >> 18403897

Oseltamivir enhances hippocampal network synchronization.

Atsushi Usami1, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki, Yuji Ikegaya.   

Abstract

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.

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Year:  2008        PMID： 18403897     DOI： 10.1254/jphs.sc0070467

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  9 in total

1.  Activation of muscarinic receptors increases the activity of the granule neurones of the rat dorsal cochlear nucleus--a calcium imaging study.

Authors:  Áron Kőszeghy; János Vincze; Zoltán Rusznák; Yuhong Fu; George Paxinos; László Csernoch; Géza Szücs
Journal:  Pflugers Arch       Date:  2012-05-01       Impact factor: 3.657

2.  Pharmacokinetic Modeling and Monte Carlo Simulation to Predict Interindividual Variability in Human Exposure to Oseltamivir and Its Active Metabolite, Ro 64-0802.

Authors:  Mototsugu Ito; Hiroyuki Kusuhara; Atsushi Ose; Tsunenori Kondo; Kazunari Tanabe; Hideki Nakayama; Shigeru Horita; Takuya Fujita; Yuichi Sugiyama
Journal:  AAPS J       Date:  2016-10-31       Impact factor: 4.009

3.  Synaptic and behavioral interactions of oseltamivir (Tamiflu) with neurostimulants.

Authors:  Y Izumi; K Tokuda; Ka O'Dell; Cf Zorumski; T Narahashi
Journal:  Hum Exp Toxicol       Date:  2008-12       Impact factor: 2.903

4.  Evaluation of [(11)C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey models of viral infection.

Authors:  Chie Seki; Arata Oh-Nishi; Yuji Nagai; Takafumi Minamimoto; Shigeru Obayashi; Makoto Higuchi; Makoto Takei; Kenji Furutsuka; Takehito Ito; Ming-Rong Zhang; Hiroshi Ito; Mototsugu Ito; Sumito Ito; Hiroyuki Kusuhara; Yuichi Sugiyama; Tetsuya Suhara
Journal:  EJNMMI Res       Date:  2014-07-02       Impact factor: 3.138

5.  Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus.

Authors:  Alina Savotchenko; Arthur Romanov; Dmytro Isaev; Oleksandr Maximyuk; Vadym Sydorenko; Gregory L Holmes; Elena Isaeva
Journal:  Neural Plast       Date:  2015-01-31       Impact factor: 3.599

6.  The inhibitory effect of kakkonto, Japanese traditional (kampo) medicine, on brain penetration of oseltamivir carboxylate in mice with reduced blood-brain barrier function.

Authors:  Kousuke Ohara; Shinji Oshima; Nanami Fukuda; Yumiko Ochiai; Ayumi Maruyama; Aki Kanamuro; Akio Negishi; Seiichi Honma; Shigeru Ohshima; Masayuki Akimoto; Shingo Takenaka; Daisuke Kobayashi
Journal:  Evid Based Complement Alternat Med       Date:  2015-02-19       Impact factor: 2.629

7.  Inhibition of MAO-A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir.

Authors:  Miki Hiasa; Yumiko Isoda; Yasushi Kishimoto; Kenta Saitoh; Yasuaki Kimura; Motomu Kanai; Masakatsu Shibasaki; Dai Hatakeyama; Yutaka Kirino; Takashi Kuzuhara
Journal:  Br J Pharmacol       Date:  2013-05       Impact factor: 8.739

8.  Analysis of a child who developed abnormal neuropsychiatric symptoms after administration of oseltamivir: a case report.

Authors:  Kaori Morimoto; Kei Nagaoka; Akira Nagai; Hirofumi Kashii; Masakiyo Hosokawa; Yukitoshi Takahashi; Takuo Ogihara; Masaya Kubota
Journal:  BMC Neurol       Date:  2015-08-05       Impact factor: 2.474

9.  Oseltamivir reduces hippocampal abnormal EEG activities after a virus infection (influenza) in isoflurane-anesthetized rats.

Authors:  Youssouf Cissé; Isao Inoue; Hiroshi Kido
Journal:  J Exp Pharmacol       Date:  2012-06-21
  9 in total

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