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Literature DB >> 18403493

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.

Hae Kyung Lee¹, Cunli Xiang, Simona Cazacu, Susan Finniss, Gila Kazimirsky, Nancy Lemke, Norman L Lehman, Sandra A Rempel, Tom Mikkelsen, Chaya Brodie.

Abstract

We characterized the expression and function of the endoplasmic reticulum protein GRP78 in glial tumors. GRP78 is highly expressed in glioblastomas but not in oligodendrogliomas, and its expression is inversely correlated with median patient survival. Overexpression of GRP78 in glioma cells decreases caspase 7 activation and renders the cells resistant to etoposide- and cisplatin-induced apoptosis, whereas silencing of GRP78 decreases cell growth and sensitizes glioma cells to etoposide, cisplatin, and gamma-radiation. Thus, GRP78 contributes to the increased apoptosis resistance and growth of glioma cells and may provide a target for enhancing the therapeutic responsiveness of these tumors.

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Year: 2008 PMID： 18403493 PMCID： PMC2563046 DOI： 10.1215/15228517-2008-006

Source DB: PubMed Journal: Neuro Oncol ISSN： 1522-8517 Impact factor: 12.300

19 in total

Review 1. Protein folding and quality control in the endoplasmic reticulum.

Authors: Bertrand Kleizen; Ineke Braakman
Journal: Curr Opin Cell Biol Date: 2004-08 Impact factor: 8.382

2. Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance.

Authors: Qi Wang; Zhongzhou He; Jinhui Zhang; Yingyan Wang; Tao Wang; Shuping Tong; Liju Wang; Shujing Wang; Yuhua Chen
Journal: Cancer Detect Prev Date: 2005-11-16

3. Secreted protein acidic and rich in cysteine promotes glioma invasion and delays tumor growth in vivo.

Authors: Chad Schultz; Nancy Lemke; Shugang Ge; William A Golembieski; Sandra A Rempel
Journal: Cancer Res Date: 2002-11-01 Impact factor: 12.701

4. Overexpression of glucose-regulated protein 78 in colon cancer.

Authors: Xiaoming Xing; Maode Lai; Yinghong Wang; Enping Xu; Qiong Huang
Journal: Clin Chim Acta Date: 2005-09-21 Impact factor: 3.786

5. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation.

Authors: Ramachandra K Reddy; Changhui Mao; Peter Baumeister; Richard C Austin; Randal J Kaufman; Amy S Lee
Journal: J Biol Chem Date: 2003-03-28 Impact factor: 5.157

6. Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells.

Authors: H Miyake; I Hara; S Arakawa; S Kamidono
Journal: J Cell Biochem Date: 2000-04 Impact factor: 4.429

Review 7. The WHO classification of tumors of the nervous system.

Authors: Paul Kleihues; David N Louis; Bernd W Scheithauer; Lucy B Rorke; Guido Reifenberger; Peter C Burger; Webster K Cavenee
Journal: J Neuropathol Exp Neurol Date: 2002-03 Impact factor: 3.685

Review 8. State-of-the-art treatment of high-grade brain tumors.

Authors: Alba A Brandes
Journal: Semin Oncol Date: 2003-12 Impact factor: 4.929

Review 9. Glioblastoma.

Authors: C Ryan Miller; Arie Perry
Journal: Arch Pathol Lab Med Date: 2007-03 Impact factor: 5.534

Review 10. Stress induction of GRP78/BiP and its role in cancer.

Authors: Jianze Li; Amy S Lee
Journal: Curr Mol Med Date: 2006-02 Impact factor: 2.222

49 in total

1. Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy.

Authors: Jonathan Asling; Jodi Morrison; Anthony J Mutsaers
Journal: Cell Stress Chaperones Date: 2016-09-08 Impact factor: 3.667

2. Class I histone deacetylases localize to the endoplasmic reticulum and modulate the unfolded protein response.

Authors: Soumen Kahali; Bhaswati Sarcar; Antony Prabhu; Edward Seto; Prakash Chinnaiyan
Journal: FASEB J Date: 2012-03-02 Impact factor: 5.191

3. Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors.

Authors: Ralph J Passarella; Daniel E Spratt; Alice E van der Ende; John G Phillips; Hongmei Wu; Vasanth Sathiyakumar; Li Zhou; Dennis E Hallahan; Eva Harth; Roberto Diaz
Journal: Cancer Res Date: 2010-05-18 Impact factor: 12.701

4. Radiation-induced tumor neoantigens: imaging and therapeutic implications.

Authors: Christopher D Corso; Arif N Ali; Roberto Diaz
Journal: Am J Cancer Res Date: 2011-01-25 Impact factor: 6.166

5. Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion.

Authors: Humsa S Venkatesh; Tessa B Johung; Viola Caretti; Alyssa Noll; Yujie Tang; Surya Nagaraja; Erin M Gibson; Christopher W Mount; Jai Polepalli; Siddhartha S Mitra; Pamelyn J Woo; Robert C Malenka; Hannes Vogel; Markus Bredel; Parag Mallick; Michelle Monje
Journal: Cell Date: 2015-04-23 Impact factor: 41.582

6. Age-Dependent Association between Protein Expression of the Embryonic Stem Cell Marker Cripto-1 and Survival of Glioblastoma Patients.

Authors: Berit B Tysnes; Hege A Satran; Sverre J Mork; Naira V Margaryan; Geir E Eide; Kjell Petersen; Luigi Strizzi; Mary J C Hendrix
Journal: Transl Oncol Date: 2013-12-01 Impact factor: 4.243

7. Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.

Authors: Enric Xipell; Tomás Aragón; Naiara Martínez-Velez; Beatriz Vera; Miguel Angel Idoate; Juan José Martínez-Irujo; Antonia García Garzón; Marisol Gonzalez-Huarriz; Arlet M Acanda; Chris Jones; Frederick F Lang; Juan Fueyo; Candelaria Gomez-Manzano; Marta M Alonso
Journal: Neuro Oncol Date: 2016-03-06 Impact factor: 12.300