INTRODUCTION: A high prevalence of nocturnal hypoxia is noted in patients with chronic heart failure (CHF). Nocturnal hypoxia can be reversed by nasal oxygen or non-invasive assisted ventilation. However, controversy exists over the use of oxygen in CHF. We studied the effects of nocturnal nasal oxygen in CHF to demonstrate its effects on 6-min walk test, quality of life (QOL), NTproBNP, and echocardiographic parameters. METHODOLOGY: Ten patients aged 70+/-9 years received domiciliary oxygen (4 l/min) for one month. Oxygen was administered for a minimum of 8h every night via nasal prongs. RESULTS: A 17% improvement was seen in the 6-min walk test, 298+/-98 m to 351+/-100 m (p=0.005) and a 27% improvement in the QOL, which improved from 26+/-12 to 19+/-7 (p=0.017). Acquired echocardiographic measures including ejection fraction, pulmonary pressure and diastolic parameters did not change. CONCLUSION: Nocturnal nasal oxygen has a significant impact on sub-maximal exercise capacity and QOL in CHF. Although a previous study has demonstrated harmful haemodynamic effects of acute oxygen administration in CHF; we did not detect any change in echocardiographic parameters using current two-dimensional imaging and Doppler studies. The lack of improvement in cardiac parameters suggests a peripheral mode of action.
INTRODUCTION: A high prevalence of nocturnal hypoxia is noted in patients with chronic heart failure (CHF). Nocturnal hypoxia can be reversed by nasal oxygen or non-invasive assisted ventilation. However, controversy exists over the use of oxygen in CHF. We studied the effects of nocturnal nasal oxygen in CHF to demonstrate its effects on 6-min walk test, quality of life (QOL), NTproBNP, and echocardiographic parameters. METHODOLOGY: Ten patients aged 70+/-9 years received domiciliary oxygen (4 l/min) for one month. Oxygen was administered for a minimum of 8h every night via nasal prongs. RESULTS: A 17% improvement was seen in the 6-min walk test, 298+/-98 m to 351+/-100 m (p=0.005) and a 27% improvement in the QOL, which improved from 26+/-12 to 19+/-7 (p=0.017). Acquired echocardiographic measures including ejection fraction, pulmonary pressure and diastolic parameters did not change. CONCLUSION: Nocturnal nasal oxygen has a significant impact on sub-maximal exercise capacity and QOL in CHF. Although a previous study has demonstrated harmful haemodynamic effects of acute oxygen administration in CHF; we did not detect any change in echocardiographic parameters using current two-dimensional imaging and Doppler studies. The lack of improvement in cardiac parameters suggests a peripheral mode of action.
Authors: Reiko Asano; Stephen C Mathai; Peter S Macdonald; Phillip J Newton; David C Currow; Jane Phillips; Wing-Fai Yeung; Patricia M Davidson Journal: Heart Fail Rev Date: 2020-03 Impact factor: 4.214
Authors: Fabio Esposito; Odile Mathieu-Costello; Ralph Shabetai; Peter D Wagner; Russell S Richardson Journal: J Am Coll Cardiol Date: 2010-05-04 Impact factor: 24.094