AIMS: The aim of this retrospective study was to investigate the correlation between MPV and the clinical disease activity indices of rheumatoid arthritis and ankylosing spondylitis. METHODS: The study consisted of 32 active RA patients (males/females: 7/25, mean age: 49+/-13) and 30 active AS patients (males/females: 15/15, mean age: 36+/-12) along with 26 osteoarthritis (OA) patients (males/females: 4/22, mean age: 52+/-8) and 29 age-matched healthy subjects (males/females: 5/24, mean age: 41+/-7) as control groups for RA and AS, respectively. RESULTS: MPV was significantly lower in both AS patients and RA patients with active disease as compared to controls (RA vs OA p<0.001, AS vs healthy subjects p<0.001). After treatment MPV values significantly increased in AS and RA (p<0.001 for all). However, MPV values remained somewhat lower in RA patients than OA patients (p=0.019). There was a negative correlation between MPV values and BASDAI scores in AS patients after two months of treatment (r=-0.507; p=0.004). CONCLUSION: Our results suggest that assessment of MPV may provide additional information about inflammation in AS and RA.
AIMS: The aim of this retrospective study was to investigate the correlation between MPV and the clinical disease activity indices of rheumatoid arthritis and ankylosing spondylitis. METHODS: The study consisted of 32 active RA patients (males/females: 7/25, mean age: 49+/-13) and 30 active AS patients (males/females: 15/15, mean age: 36+/-12) along with 26 osteoarthritis (OA) patients (males/females: 4/22, mean age: 52+/-8) and 29 age-matched healthy subjects (males/females: 5/24, mean age: 41+/-7) as control groups for RA and AS, respectively. RESULTS: MPV was significantly lower in both AS patients and RA patients with active disease as compared to controls (RA vs OA p<0.001, AS vs healthy subjects p<0.001). After treatment MPV values significantly increased in AS and RA (p<0.001 for all). However, MPV values remained somewhat lower in RA patients than OA patients (p=0.019). There was a negative correlation between MPV values and BASDAI scores in AS patients after two months of treatment (r=-0.507; p=0.004). CONCLUSION: Our results suggest that assessment of MPV may provide additional information about inflammation in AS and RA.
Authors: Serdar Soydinc; Ibrahim Halil Turkbeyler; Yavuz Pehlivan; Gulcimen Soylu; Mehmet Fatih Goktepe; Muhammed Bilici; Orhan Zengin; Bunyamin Kisacik; Ahmet Mesut Onat Journal: Inflammation Date: 2014-02 Impact factor: 4.092
Authors: Khader Shameer; Joshua C Denny; Keyue Ding; Hayan Jouni; David R Crosslin; Mariza de Andrade; Christopher G Chute; Peggy Peissig; Jennifer A Pacheco; Rongling Li; Lisa Bastarache; Abel N Kho; Marylyn D Ritchie; Daniel R Masys; Rex L Chisholm; Eric B Larson; Catherine A McCarty; Dan M Roden; Gail P Jarvik; Iftikhar J Kullo Journal: Hum Genet Date: 2013-09-12 Impact factor: 4.132
Authors: Adnan Incebiyik; Ahmet Seker; Mehmet Vural; Nese Gul Hilali; Aysun Camuzcuoglu; Hakan Camuzcuoglu Journal: Wien Klin Wochenschr Date: 2014-06-24 Impact factor: 1.704