| Literature DB >> 18402480 |
Amal I Siriwardana1, Ian R Crossley, Angel A J Torriero, Iko M Burgar, Noel F Dunlop, Alan M Bond, Glen B Deacon, Douglas R Macfarlane.
Abstract
The alkylation reaction of 2-mercapto-1-methylimidazole 1a with iodoethane and chlorobutane produced S-alkylmethimazole halides 2a and 2b which were subjected to anion metathesis with two different metal salts (MA) to afford methimazole-based room-temperature ionic liquids 3a, 3b, and 3c in 82%, 85%, and 87% yields, respectively. S-Alkylation giving 2a and 2b suggests that methimazole reacts through the thione tautomer.Entities:
Year: 2008 PMID： 18402480 DOI： 10.1021/jo702511v
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354