Literature DB >> 1840236

The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14.

Y H Edwards1, M F Fox, S Povey, L J Hinks, R J Thompson, I N Day.   

Abstract

Ubiquitin carboxy terminal hydrolase 1, UCHL1, is a neurone-specific protein involved in the ubiquitin-mediated proteolytic pathway. The gene for human UCHL1 has been mapped to chromosome 4 using the polymerase chain reaction to amplify specifically the human UCHL1 sequences in rodent/human somatic cell hybrid DNA. A regional assignment of this locus to 4p14 has been made by in situ hybridization to metaphase chromosomes using both tritium and fluorescently labelled probes.

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Year:  1991        PMID： 1840236     DOI： 10.1111/j.1469-1809.1991.tb00853.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  3 in total

1.  Porcine UCHL1: genomic organization, chromosome localization and expression analysis.

Authors:  Knud Larsen; Lone Bruhn Madsen; Christian Bendixen
Journal:  Mol Biol Rep       Date:  2011-05-13       Impact factor: 2.316

2.  Target genes of neuron-restrictive silencer factor are abnormally up-regulated in human myotilinopathy.

Authors:  Marta Barrachina; Jesús Moreno; Salvador Juvés; Dolores Moreno; Montse Olivé; Isidre Ferrer
Journal:  Am J Pathol       Date:  2007-09-06       Impact factor: 4.307

3.  The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.

Authors:  Tingxiu Xiang; Lili Li; Xuedong Yin; Chenfu Yuan; Cui Tan; Xianwei Su; Lei Xiong; Thomas C Putti; Michael Oberst; Kathleen Kelly; Guosheng Ren; Qian Tao
Journal:  PLoS One       Date:  2012-01-18       Impact factor: 3.240
  3 in total

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