Literature DB >> 1840207

Changes in the level of IL-2, T cell subsets and the function of T suppressor cells in patients with schistosomiasis japonica.

Z J Li1, J Z Dai, Y X Yang, L L Zeng, S L Li, Q Yang, H C Wang, D D Luo, X H Wang.   

Abstract

The level of interleukin-2 (IL-2) produced by peripheral blood mononuclear cells in vitro, T cell subsets and the function of T suppressor cells (Ts) in patients with schistosomiasis japonica were investigated. It was found that the level of IL-2 induced by schistosomal antigens was significantly high and positively related to the percentage of CD4+ cells. In the groups of chronic and advanced schistosomiasis japonica, the level of IL-2 induced by schistosomal antigens was markedly lower than that in the group of acute schistosomiasis japonica, but significantly higher than that in the group of normal controls. The IL-2 level was negatively related to the percentage of CD8+ T cells and the ratio of CD4+/CD8+. The level of IL-2 induced by PHA was greatly reduced in the group of advanced schistosomiasis japonica. The changes in the level of IL-2 and its relationship with T cell subsets and the function of Ts are also discussed.

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Year:  1991        PMID： 1840207     DOI： 10.1007/bf02888157

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  9 in total

1.  Deficiency of interleukin-2 activity upon addition of soluble egg antigen to cultures of spleen cells from mice infected with Schistosoma japonicum.

Authors:  A B Stavitsky; W W Harold
Journal:  Infect Immun       Date:  1988-07       Impact factor: 3.441

2.  T cell growth factor: parameters of production and a quantitative microassay for activity.

Authors:  S Gillis; M M Ferm; W Ou; K A Smith
Journal:  J Immunol       Date:  1978-06       Impact factor: 5.422

3.  Lymphocyte responsiveness to phytohemagglutinin and to worm and egg antigens in human schistosomiasis japonica.

Authors:  R M Lewert; M G Yogore; B L Blas
Journal:  Am J Trop Med Hyg       Date:  1979-01       Impact factor: 2.345

Review 4.  Molecular characterization of interleukin 2.

Authors:  S Gillis; D Y Mochizuki; P J Conlon; S H Hefeneider; C A Ramthun; A E Gillis; M B Frank; C S Henney; J D Watson
Journal:  Immunol Rev       Date:  1982       Impact factor: 12.988

5.  Spontaneous and conA-induced suppressor lymphocytes: a comparative study.

Authors:  C Gattringer; H Huber; G Michlmayr; H Braunsteiner
Journal:  Immunobiology       Date:  1981       Impact factor: 3.144

6.  Release of interleukin 2 and gamma interferon by peripheral mononuclear cells in human Schistosoma mansoni infection normalizes after chemotherapy.

Authors:  K Zwingenberger; E Irschick; J G Siqueira Vergetti; A R Correia Dacal; R Janssen-Rosseck; U Bienzle; C Huber; H Feldmeier
Journal:  Scand J Immunol       Date:  1989-10       Impact factor: 3.487

7.  Immune responses during human Schistosomiasis mansoni. XI. Immunologic status of patients with acute infections and after treatment.

Authors:  G Gazzinelli; J R Lambertucci; N Katz; R S Rocha; M S Lima; D G Colley
Journal:  J Immunol       Date:  1985-09       Impact factor: 5.422

8.  Deficiency of interleukin-2 production upon addition of soluble egg antigen to cultures of isolated hepatic granulomas or hepatic granuloma cells from mice infected with Schistosoma japonicum.

Authors:  A B Stavitsky; W W Harold
Journal:  Infect Immun       Date:  1989-08       Impact factor: 3.441

9.  Changes in T cell subsets and T suppressor cell function and their relationship in human schistosomiasis japonica.

Authors:  Z J Li; D D Luo; J Z Dai; L L Zheng; X H Wang; Y X Yang
Journal:  J Tongji Med Univ       Date:  1991
  9 in total

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